A novel model coupled with a population balance equation is adopted for simulating the aggregation process and flow behavior of cohesive powders in a full-loop circulating fluidized bed. The agglomerate diameter is calculated according to the change of particle number by a population balance equation which is solved as a part of computational fluid dynamics simulation. The solid pressure and viscosity are redefined by taking the effect of interparticle force into consideration based on the kinetic theory of granular flow. Simulation results of time-averaged solid volume fraction and diameter of agglomerate are predicted by a numerical method and are in reasonable agreement with experimental data. The variation of mass flux, solid pressure, and viscosity under different operating conditions are analyzed based on the proposed model.