CHUPINÅbstract. In this paper, we present some mathematical results on the Doi-Edwards model describing the dynamics of flexible polymers in melts and concentrated solutions. This model, developed in the late 1970s, has been used and tested extensively in modeling and simulation of polymer flows. From a mathematical point of view, the Doi-Edwards model consists in a strong coupling between the Navier-Stokes equations and a highly nonlinear constitutive law. The aim of this article is to provide a rigorous proof of the well-posedness of the Doi-Edwards model, namely it has a unique regular solution. We also prove, which is generally much more difficult for flows of viscoelastic type, that the solution is global in time in the two dimensional case, without any restriction on the smallness of the data.