“…For example, numerical analysis of a saponification reaction in dilute solution coupled a finite-difference time-domain solver to a thermal transport solver and a chemical solver based on the rate equation, but the results were restricted to a small temperature change of less than 10 °C, starting from room temperature . To the best of our knowledge, there has been little further progress on coupling to numerical chemical solvers, with attention instead focusing on coupling via Navier–Stokes equations to fluid flow in liquids. , …”