Recently, there has been a growing interest in the use of sandwich panels that, beyond handling well-known bending stress, can withstand torsional stresses. This is particularly relevant for wall applications when the panels are equipped with photovoltaic or supplemental curtain wall modules. This research article presents a detailed exploration of the structural behavior of eccentrically loaded sandwich panels, with a specific focus on warping torsion. Experimental and numerical studies were conducted on polyisocyanurate (PU) core sandwich panels, commonly employed in building envelopes. These studies involved various dimensions and material properties, while omitting longitudinal joints. The experimental study provided essential insights and validated the numerical model in ANSYS. Enabling parametric variation, the numerical analysis extends the analysis beyond the experimental scope. Results revealed a high degree of correlation between experimental, numerical, and analytical solutions, regarding the rotation, as well as the normal and shear stress of the panel. Confirming the general applicability of warping torsion in sandwich panels with certain limitations, the study contributes valuable data for applications and design of eccentrically loaded sandwich panels, laying the foundation for potential engineering calculation methods.