In this paper, Cubic B-Spline collocation method (CBSCM) and Adomian Decomposition Method (ADM) are applied to obtain numerical solutions to fourth-order linear and nonlinear differential equations. The CBSCM was based on finite element method involving collocation method with cubic B-spline as a basis function. While ADM was based on multistage decomposition method. We discovered in the illustrative examples considered, that result by ADM were compatible with the closed form solutions well over twenty, in some cases over thirty, decimal places and with extremely minimal absolute errors. Results by CBSCM gave correct solutions to atmost six decimal places with sizeable absolute errors. These has further revealed the importance and superiority of ADM over CBSCM in providing semi-analytic solution to this class of differential equations.