This study deals with the investigation of MHD flow of Williamson fluid over an infinite rotating disk with the effects of Soret, Dufour, and anisotropic slip. The anisotropic slip and the Soret and Dufour effects are the primary features of this study, which greatly influence the flow, heat and mass transport properties. In simultaneous appearance of heat and mass transfer in a moving fluid, the mass flux generated by temperature gradients is known as the thermal-diffusion or Soret effect and the energy flux created by a composition gradient is called the diffusion-thermo or Dufour effect, however, difference in slip lengths in streamwise and spanwise directions is named as anisotropic slip. The system of nonlinear partial differential equations (PDEs), which governs the flow, heat and mass transfer characteristics, is transformed into ordinary differential equations (ODEs) with the help of von Kármán similarity transformation. A numerical solution of the complicated ODEs is carried out by a MATLAB routine bvp4c. The obtained results of velocity, temperature, concentration, and some physical quantities are displayed through graphs and tables, and their physical discussion is presented.