The concepts of isolated self-gravitating system, asymptotic flatness and asymptotic simplicity are reconsidered, various related results are discussed and put into perspective, basic open questions are discussed.MSC 83C05, 83C30, 83C35 * Extended version of a talk given at the symposium honoring Piotr T. Chruściel on the occasion of his 60th birthday, 17th -18th August 2017.