In the era of space exploration, the scientific community is strongly focusing on the analysis of hypersonic flows in the presence of shock wave/boundary layer interaction. In these conditions, the flow field presents a complex shock structure due to the interaction of different shock waves with the boundary layer. The strong adverse pressure gradient makes the boundary layer separate, giving rise to a separation bubble. In the reattachment zone, the temperature can reach very high values, inducing thermochemical non-equilibrium effects. This research field is recently achieving more and more relevance in aerospace research, as the analysis of turbulent shock wave/boundary layer interaction so far has been mainly focused on perfect gas flows. In this manuscript, a Reynolds averaged Navier–Stokes (RANS) approach is considered, the shear stress transport (SST) model being coupled with the multitemperature approach proposed by Park to investigate thermochemical non-equilibrium effects in hypersonic turbulent shock wave/boundary layer interaction. The first part of the manuscript is devoted to the validation of the solver, and results for low enthalpy flat plate and compression ramp flows are presented. The numerical results are shown to be in good agreement with numerical solutions and experimental measurements. Afterward, the free stream conditions are modulated to make non-equilibrium relevant and analyze a reacting flow.