The aero-engine wide-chord hollow fan blade with a cavity stiffener structure can effectively reduce the weight and greatly increase the rotational speed. However, during the high-speed rotation process of the hollow fan, there is a strong coupling effect between the solid domain of the blade and the incoming air. This effect leads to a certain deformation of the rotor blade, which has a large impact on the structural strength of the blade. Aiming at the problem of the fluid–structure interaction in its operation, the finite-element method was used to simulate the two-layer structure of the TC4 titanium alloy wide-chord hollow fan blade. The centrifugal force and fluid–structure coupling effect were considered when carrying out the research on the structural mechanical characteristics of the blade. The results show that the maximum equivalent stress of the blade considering the fluid–structure coupling effect is 508 MPa at the rotational speed of 2,900 r/min, which is approximately 18% higher than the maximum stress when only the centrifugal force is considered. This phenomenon indicates that the effect of aerodynamic force on the blade stress cannot be ignored. The stress concentration area of the blade is located in the third stiffener from the leading edge and near the root of the blade, and the aerodynamic force has a more significant effect on the radial stress distribution of the blade. Further analysis of the equivalent stress distribution along the blade tip direction shows a trend of first increasing and then decreasing. The maximum equivalent stress appears at a distance of 30 mm up to the bottom of the stiffener.