Numerical study of magnetic nanoparticles concentration in biofluid (blood) under influence of high gradient magnetic field

Habibi, Mohammad Reza; Ghasemi, Majid

doi:10.1016/j.jmmm.2010.08.023

Cited by 41 publications

(10 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the similar purpose of magneticallyinduced mixing, Finite Volume Method (FVM) was used by Le et al for solving the flow and concentration field with an implicit scheme [21]. A finite volume based code was also developed and utilized for investigating the effect of a magnetic field on the concentration field of magnetic nanoparticles [22]. In a recent work, the drift-diffusion equation was numerically solved while the magnetic field and force were obtained from an analytical model [23].…”

Section: Introductionmentioning

confidence: 99%

Magnetofluidic spreading in microchannels

Zhu

Nguyen

2012

Microfluid Nanofluid

View full text Add to dashboard Cite

We investigate the spreading phenomena caused by the interaction between a uniform magnetic field and a magnetic fluid in microchannels. The flow system consists of two liquids: a ferrofluid and a mineral oil. The ferrofluid consists of super paramagnetic nanoparticles suspended in an oil-based carrier. Under a uniform magnetic field, the super paramagnetic particles are polarized and represent magnetic dipoles. The magnetization of the magnetic nanoparticles lead to a force resulting in the change of diffusion behavior inside the microchannel. Mixing due to secondary flow close to the interface also contributes to the spreading of the ferrofluid. The magnetic force acting on the liquid/liquid interface is caused by the mismatch of magnetization between the nanoparticles and surrounding liquid in a multiphase flow system. This paper examines the roles of magnetic force in the observed spreading phenomena. The effect of particles on the flow field is also considered. These phenomena would allow simple wireless control of a microfluidic system without changing the flow rates. These phenomena can potentially be used for focusing and sorting in cytometry.

show abstract

Section: Introductionmentioning

confidence: 99%

Magnetofluidic spreading in microchannels

Zhu

Nguyen

2012

Microfluid Nanofluid

View full text Add to dashboard Cite

show abstract

“…M. R. Habibi and M. Ghassemi studied numerically the concentration of magnetic nanoparticles travelling in non-Newtonian biofl uid under the infl uence of magnetic fi eld in vitro and in vivo [4]. Biocompatibility and biotranslocation issues in relation to chemo-physical properties of MNPs, including particle size, surface properties, shape and structure, are discussed.…”

Section: Introductionmentioning

confidence: 99%

“…The motivation for this theoretical study is a design of robust algorithms needed to evaluate parameters of magnetically-driven systems for a particular biomedical application with actual complexity and real geometry, such as magnetic drug delivery and treatment [1][2][3][4][5][6][7], monitoring and control of brain tissue cleansing from metabolites and toxins, activation of brain drainage function [9], magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues [10], magnetomotive DOCT for imaging of melanoma-implanted magnetic nanoparticles [11], and magnetomotive laser speckle imaging [12].…”

Section: Introductionmentioning

confidence: 99%

Trapping of Magnetic Nanoparticles in the Blood Stream under the Influence of a Magnetic Field

Salem¹,

Tuchin²

2020

ISUNSSP

View full text Add to dashboard Cite

Magnetic nanoparticles, as controlled drug carriers, provide tremendous opportunities in treating a variety of tumors and brain diseases. In this theoretical study, we used magnetic nanoparticles, such as Superparamagnetic Iron Oxide Nanoparticles (Fe 3 O 4) (SPION). Due to their biocompatibility and stability, these particles represent a unique nanoplatform with a great potential for the development of drug delivery systems. This allows them to be used in medicine for targeted drug delivery, in magnetic resonance imaging and magnetic hyperthermia. In the work, the trapping mechanisms of magnetic nanoparticles moving in a viscous fluid (blood) in a static magnetic field are numerically studied. The equations of motion for particles in the flow are governed by a combination of magnetic equations for the permanent magnet field and the Navier-Stokes equations for fluid (blood). These equations were solved numerically using the COMSOL Multiphysics® Modeling Software.

show abstract

“…Kenjereš [ 25 ] presented a numerical analysis of blood flow in realistic arteries subjected to strong nonuniform magnetic field. Habibi and Ghasemi [ 26 ] investigated the effect of a magnetic field on the volume concentration of magnetic nanoparticles of a non-Newtonian blood. Kwon et al [ 27 ] studied the effect of blood viscosity on oxygen transport in residual stenosed artery.…”

Section: Introductionmentioning

confidence: 99%

Simulations of Magnetohemodynamics in Stenosed Arteries in Diabetic or Anemic Models

Alshare

Tashtoush

2016

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

Pulsatile flow simulations of non-Newtonian blood flow in an axisymmetric multistenosed artery, subjected to a static magnetic field, are performed using FLUENT. The influence of artery size and magnetic field intensity on transient wall shear stress, mean shear stress, and pressure drop is investigated. Three different types of blood, namely, healthy, diabetic, and anemic are considered. It is found that using Newtonian viscosity model of blood in contrast to Carreau model underestimates the pressure drop and wall shear stress by nearly 34% and 40%, respectively. In addition, it is found that using a magnetic field increases the pressure drop by 15%. Generally, doubling the artery diameter reduces the wall shear stress approximately by 1.6 times. Also increasing the stenosis level from moderate to severe results in reduction of the shear stress by 1.6 times. Furthermore, doubling the diameter of moderately stenosed artery results in nearly 3-fold decrease in pressure drop. It is also found that diabetic blood results in higher shear stress and greater pressure drop in comparison to healthy blood, whereas anemic blood has a decreasing effect on both wall shear stress and pressure drop in comparison to healthy blood.

show abstract

Numerical study of magnetic nanoparticles concentration in biofluid (blood) under influence of high gradient magnetic field

Cited by 41 publications

References 9 publications

Magnetofluidic spreading in microchannels

Magnetofluidic spreading in microchannels

Trapping of Magnetic Nanoparticles in the Blood Stream under the Influence of a Magnetic Field

Simulations of Magnetohemodynamics in Stenosed Arteries in Diabetic or Anemic Models

Contact Info

Product

Resources

About