Bubble breakup in a four-branched microchannel with carboxymethyl cellulose (CMC) solution was investigated by an improved coupled level set and volume of fluid (CLSVOF) method based on consideration of the rheological characteristic of the fluid. The validity of the numerical approach was satisfactorily verified by comparing with the experimental results. The regime and pattern of bubble breakup were evaluated by analyzing the evolution of bubble morphology. The effects of gas velocity, solution concentration, and subchannel width on daughter bubble length were examined, respectively. The results indicate that three split regimes at the branch comprising expansion, squeezing, and pinch-off stage and three flow patterns including long slug, short slug, and bubble flows can be observed. Daughter