In the case of interior fire in an apartment building, contamination of vestibule area by fire smoke before air fan operating when fire doors are open makes the evacuation of people very difficult. In order to investigate the effect of heat release rate (HRR) and interior opening on fire flow velocity, numerical simulations using Fire Dynamics Simulator were carried out. In simulations, actual dimensions and configuration of an apartment building were considered and interior leakage and HRR were varied. From simulation results, it was found that fire flow velocity distribution is significantly influenced by HRR and interior opening resulting in the change of the location of a neutral plane. Also, it is shown that there is a larger difference of the fire flow velocity between upper and lower part of the fire door when the neutral plane becomes closer to the ceiling.