Experimental analyses and numerical simulations are carried out on a test case involving an heptane pool fire within a large under-ventilated environment. During the experiments, the temperature history at several locations within the room is monitored by means of thermocouples, and the fire radiative heat transfer estimated through a plate thermocouple. The experimental layout is then replicated numerically and tested using OpenFOAM CFD code. The study is a preliminary analysis performed for code validation purposes on a full-scale fire scenario. The results of the simulations are compared to the experimental results and critically analysed, finding a reasonable agreement overall. Critical issues in fire modelling are also highlighted. In fact, due to the problem complexity and the limitations of the numerical models available some important aspect that can significantly influence the outcome of the simulations must be calibrated a posteriori, somewhat limiting the general predictive applicability of the fire models. Primarily, these are the heat release rate history, the combustion efficiency, and, to a lesser extent, the convective heat transfer boundary condition at the wall.