In order to meet the requirement of coal mine flooding emergency rescue, a high-power, high-head, and small-volume high-speed wet submersible pump has been designed. This article provides comparison and analysis for nine combination cases of different matching laws between the impeller blade number Z 1 (Z 1 = 5, 6, 7) and the diffuser vane blade number Z 2 (Z 2 = 8, 9, 10). The comparison of the pump performance and inner flow characters, such as the head, efficiency, radial force, and pressure pulsation coefficient, at different blade number matching of impeller and diffuser has been studied by the computational fluid dynamics software CFX. These are solved through the three-dimensional unsteady Reynolds-averaged Navier-Stokes equations with the shear-stress transport k-v turbulence model. Furthermore, the computational fluid dynamics method is validated by experimental data collected in the laboratory. The results show that the combination of blade number of impeller and diffuser vane has a significant effect on the behavior. The steady analysis of combinations indicates that an increased efficiency occurs along with the reduced blade number. From the unsteady perspective, the 7 + 8 (Z 1 = 7, Z 2 = 8) case has the lowest fluctuation and relatively small radial force. In conclusion, the above results can provide reference for choosing blade numbers matching law between impeller and diffuser vane of the high-speed rescue pump.