Numerical Study of Titanium Dioxide and MXene Nanomaterial-Based Surface Plasmon Resonance Biosensor for Virus SARS-CoV-2 Detection

Abstract

A novel surface plasmon resonance-based biosensor for SARS-CoV-2 virus is proposed in this article. The biosensor is a Kretschmann configuration-based structure that consists of CaF 2 prism as base, at which silver (Ag), TiO 2 , and MXene nanolayers are used to enhance the performance. Theoretically, the performance parameters have been investigated by means of Fresnel equations and transfer matrix method (TMM). The TiO 2 nanolayer not only prevents oxidation of Ag layer but also enhances the evanescent field in its vicinity. The sensor provides an ultrahigh angular sensitivity of 346°/RIU for the detection of SARS-CoV-2 virus. Some other performance parameters, including FWHM (full width at half maxima), detection accuracy (DA), limit of detection (LOD), and quality factor (QF) have also been calculated for proposed SPR biosensor with their optimized values 2.907°, 0.3439 deg −1 , 1.445 × 10 −5 , and 118.99 RIU −1 , respectively. The obtained results designate that the proposed surface plasmon resonance (SPR) based biosensor has notably enhanced angular sensitivity as compared to previous results reported in the literatures till date. This work may facilitate a significant biological sample sensing device for fast and accurate diagnosis at early stage of SARS-CoV-2 virus.

Engineered two-dimensional nanomaterials based diagnostics integrated with internet of medical things (IoMT) for COVID-19

“…The SPR biosensor under consideration has the potential to facilitate precise detection of the SARS-CoV-2 virus in its early stages, hence aiding in the timely identification of COVID-19 patients. 349 Recent research demonstrated the remarkable sensitivity of MXenes, Nb 2 C, and Ta 2 C in the context of SERS for virus identification. The substrates exhibit noteworthy SERS enhancement, which is accomplished through charge transfer resonance enhancement and electromagnetic enhancement.…”

“…The SPR biosensor under consideration has the potential to facilitate precise detection of the SARS-CoV-2 virus in its early stages, hence aiding in the timely identification of COVID-19 patients. 349…”

Surface Plasmon Resonance Biosensor with High Sensitivity for Detecting SARS-CoV-2

“…The refractive index of the CaF 2 prism is as [5,7], Here, refractive index of BaTiO 3 is 2.404 [6]. Also, transition metal dichalcogenides WS 2 layer is used.…”

“…FWHM represents the full width at half maximum of the SPR curve, a dimensionless parameter. The quality factor (Q) is de ned as the ratio of sensitivity (S) to the FWHM of the re ectance curve [5].…”

“…There remains a pressing need for ultra-sensitive, real-time, point-of-care diagnostic methods to further assist healthcare practitioners in combating COVID-19. Surface plasmon resonance (SPR) biosensor an optical based biosensor is proposed as a promising alternative technique for detecting COVID-19 [4][5][6][7][8][9][10].…”