Numerical study on the cell motility interacting with the chemical flow in microchannels

Li, Peiye; Du, Xiaohui; Hu, Yandong; Zhao, Shengfeng

doi:10.1007/s10404-017-1893-8

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…Concentration gradients based on microfluidic systems have been extensively studied, such as the establishment of cell culture chambers in microchannels [20], the study of the interaction between cell motility and concentration gradients in microchannels [21], mutual diffusion of proteins [22], and the transport of solid-state nanoporins by electrolyte concentration [23]. Concentration gradient generation is mainly based on the single-phase method [24], which generates a concentration gradient through a series of splits, combinations, and mixing in microchannels, and the process is easy to block [7,25].…”

Section: Introductionmentioning

confidence: 99%

An embedded obstacle type micromixer‐concentration gradient generator based on capillary driven

Huang,

Wu,

Wang

et al. 2023

Electrophoresis

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An embedded obstacle‐type micromixer‐concentration gradient generator based on capillary self‐driven is proposed and studied. Herringbone structure (HS) for mixing and palisade‐shape small channels at the outlet are designed in the device (named HS). Simulation and experimentation are done to study the liquid mixing efficiency in the small channels and concentration gradient at the outlet, and the experimental results agree with the simulation results. For three cases of liquid dripping (sequential, reverse, and delayed drippings), mixing analysis shows that the mixing efficiency increases along both mixing channel and palisade length, and is high in the middle small channel of the palisade‐shape area and low on both sides. An obvious concentration gradient at the outlet can form compared with the device without the palisade‐shape area. Finally, water pH value detection is done as one of the applications of HS. This study can provide guidance for the application of HS in biochemical detection, cell research, drug screening, etc. based on the capillary‐driven effect.

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