The stratum uneven settlement of tunnel is main factors that cause damage of tunnel longitudinal structure. a 3d numerical model is established for the force and deformation calculation of tunnel structure based on the elastoplastic theory. In the model, soil material is elastoplastic, and its constitutive model is Mohr Coulomb, the element type of soil is a three-dimensional solid, the element type of tunnel lining structure is space shell element, and tunnel settlement joint is three-dimensional linear spring. Calculation shows that, this calculation model is able to fully consider the impact of tunnel uneven settlement in all factors, and can simulate the vertical force and deformation behavior of tunnel structure in complex ground formation conditions. Research conclusion gives the vertical force and deformation of the tunnel structure under the condition of the stratum uneven settlement. It is very important reference for the longitudinal design and calculation of the tunnel lining structure.