In this study, a numerical investigation on mixed convection in vertical channel with water-alumina (Al2O3) nanofluids due to the interaction between a buoyancy-driven flow and a moving plate-induced one in a vertical channel is performed. One of the plates that bound the channel is heated by a constant heat flux, while the other, considered adiabatic, moves with a constant velocity in the direction of the buoyancy force or in the opposite direction, with a comparison between the two options. The nanofluid is modelled using the Single-Phase Model. The thermophysical properties are assumed to be constant with temperature, and the fluid flow is considered laminar and incompressible. The governing equations are numerically solved with the finite volume method by means of the ANSYS-FLUENT code. The channel can have three different aspect ratios, ranging between 5 to 20, while the two external reservoirs allow simulating the external ambient and assigning a velocity of zero and the ambient temperature at the boundary of the reservoirs. The impacts of the different values of aspect ratio of the channel, wall heat flux, moving plate velocity, and concentration of the nanoparticles are investigated. Results in terms of temperature and velocity are provided. Finally, correlations for predicting of the average Nusselt number along the heated plate are proposed.