The reliability of door sealing plays an important role in maintaining the quality of vehicle noise, vibration, and harshness (NVH). To improve the reliability of door sealing, a novel sealing process has been proposed. The factors influencing the door sealing quality have been investigated. The relationships between the peeling force, peeling speed, and peeling time have been calculated using the five-variable rheological theory. The maximum stress versus time curve and the distribution of stress and strain at the moment of debonding have been obtained by nonlinear solid cohesive coupling dynamics simulation. The rolling process of the door sealing strip has been developed, and automatic rolling equipment for door sealing has been designed and manufactured. The factors influencing the peeling force have been determined by a peeling test of the door sealing strip. The results show that the peeling force increases with an increase in the peeling speed and time. The C-shaped structure at the front end of the base material during the stripping process makes the peeling angle sharp. In addition, the uneven stripping speed causes the stripping line to become irregular. The peeling force increases with the increase in rolling pressure and failure time. The optimum rolling pressure was 70 N/m2 and the optimum aging time was 24 h.