2003
DOI: 10.1261/rna.2141503
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Numerous microRNPs in neuronal cells containing novel microRNAs

Abstract: Spinal muscular atrophy (SMA) is a common neurodegenerative disease that is caused by deletions or loss-of-function mutations in the Survival of Motor Neuron (SMN) protein. SMN is part of a large complex that functions in the assembly/restructuring of ribonucleoprotein (RNP) complexes. We recently showed in HeLa cells that two components of the SMN complex, Gemin3 and Gemin4, together with the argonaute protein eIF2C2, also associate with microRNAs (miRNAs) as part of a novel class of RNPs termed miRNPs. Here … Show more

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Cited by 337 publications
(242 citation statements)
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“…The increasing number and diversity of miRNAs suggests that they play a role in the regulation of many genes in key pathways in a wide variety of cellular processes such as cell cycle control, apoptosis, 18 haematopoiesis, 2,19 adipocyte differentiation 20 and insulin secretion. 21 There is a growing number of reports that link miRNAs to the regulation of pathways associated with human diseases such as cancer, 22 neurological diseases 23 and most recently also with viral 24 and metabolic diseases. 21 As yet, however, there is not conclusive evidence that causatively links the malfunction of a miRNA or a miRNA target site to the development of a human disease.…”
Section: Mirna and Their Potential Role In Diseasesmentioning
confidence: 99%
“…The increasing number and diversity of miRNAs suggests that they play a role in the regulation of many genes in key pathways in a wide variety of cellular processes such as cell cycle control, apoptosis, 18 haematopoiesis, 2,19 adipocyte differentiation 20 and insulin secretion. 21 There is a growing number of reports that link miRNAs to the regulation of pathways associated with human diseases such as cancer, 22 neurological diseases 23 and most recently also with viral 24 and metabolic diseases. 21 As yet, however, there is not conclusive evidence that causatively links the malfunction of a miRNA or a miRNA target site to the development of a human disease.…”
Section: Mirna and Their Potential Role In Diseasesmentioning
confidence: 99%
“…This mechanism was first demonstrated in C. elegans, in which the short non-protein coding RNAs lin-4 and let-7 are used to time development programs by regulating the stage at which lin-14, lin-28 and lin-41 messages are translated 27 . These RNAs are microRNAs (miRNAs) [27][28][29][30] , which are encoded genomically as short inverted repeats that have a dsRNA stem of about 70 bp. They are found in introns as well as in intergenic clusters 29,31 .…”
Section: Rna-directed Rna Readoutmentioning
confidence: 99%
“…These RNAs are microRNAs (miRNAs) [27][28][29][30] , which are encoded genomically as short inverted repeats that have a dsRNA stem of about 70 bp. They are found in introns as well as in intergenic clusters 29,31 . The precursors are processed by dicer and other RNase III family members to produce effectors of 21-25 nucleotides derived usually from one strand of the stem 32 .…”
Section: Rna-directed Rna Readoutmentioning
confidence: 99%
“…miRNAs also appear to have important roles in the mammalian central nervous system (CNS). Numerous miRNAs are expressed in the CNS [22][23][24], and many neural miRNAs are expressed in spatial and/or temporal patterns that suggest roles in the regulation of CNS development [25][26][27][28][29][30]. MiRNA miR-132 has been shown to regulate neuronal morphogenesis through decreasing levels of GTPase-activating protein, p250GAP [31] and (along with miR-219) has been implicated in the regulation of circadian rhythms [32].…”
Section: Introductionmentioning
confidence: 99%