2024
DOI: 10.3389/fonc.2024.1371980
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NUP214 fusion genes in acute leukemias: genetic characterization of rare cases

Marta Brunetti,
Kristin Andersen,
Signe Spetalen
et al.

Abstract: IntroductionAlterations of the NUP214 gene (9q34) are recurrent in acute leukemias. Rearrangements of chromosomal band 9q34 targeting this locus can be karyotypically distinct, for example t(6;9)(p22;q34)/DEK::NUP214, or cryptic, in which case no visible change of 9q34 is seen by chromosome banding.MethodsWe examined 9 cases of acute leukemia with NUP214 rearrangement by array Comparative Genomic Hybridization (aCGH), reverse-transcription polymerase chain reaction (RT-PCR), and cycle sequencing/Sanger sequenc… Show more

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