Nup88 Expression is Associated With Myometrial Invasion in Endometrial Carcinoma

Schneider, J.; Martínez-Arribas, Fernando; Torrejón, Rafael

doi:10.1111/igc.0b013e3181dfaa6b

Cited by 16 publications

(9 citation statements)

References 9 publications

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“…Overall, the inconsistencies observed with MI may be due to differences in stage or grade amongst selected patients and the various definitions of MI; depths of >1/3 (26), >50% (22) and ≥66% (18) are all regarded as cut-off values for deep MI in various studies, indicating that in endometrial cancer, the depth of MI has various roles according to the severity of the disease. In previous studies MI has been associated with certain biochemical indicators, including levels of free insulin-like growth factor-1 plasma (27), nucleoporin (88kDa)-mRNA expression (28) and endoplasmic reticulum-β (29). An association was also demonstrated between tumor-associated macrophages and depth of MI (30).…”

Section: A B Cmentioning

confidence: 86%

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

Wang

Nan

et al. 2016

Oncology Letters

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Abstract. The aim of the present study was to determine risk factors associated with recurrence and survival in patients with grade 3 endometrioid endometrial carcinoma (G3EEC). A retrospective analysis of 117 patients with G3EEC, who were admitted to the Obstetrics and Gynecology Hospital of Fudan University between January 2000 and December 2011, was performed. The χ 2 test or Fisher's exact test were used for the comparison of categorical variables. Kaplan-Meier method was used for estimating recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) rates. Univariate and multivariate Cox proportional hazards model were used to assess the prognostic significance of various patient characteristics. In 117 patients, 16 patients (13.7%) had tumor recurrence, of which 6 (37.5%) developed local-regional recurrence and 10 (62.5%) developed distant recurrence. Out of the 16 patients with tumor recurrence, 14 (87.5%) had a recurrence within 3 years of surgery. Statistically significant characteristics affecting RFS, DSS and OS rates were outer half myometrial invasion (MI ≥50%), advanced International Federation of Gynecology and Obstetrics stage, positive lymph node metastasis (PLNM), lymph vascular space invasion, adnexal involvement and characterization as a high-risk group, according to the Gynecologic Oncology Group 99 stratification algorithm. RFS was associated with the depth of cervical mucosa (stromal) involvement. Furthermore, in the multivariate Cox proportional hazards model, significant independent adverse factors for RFS and DSS included MI ≥50% and adnexal involvement. For OS, there were no statistically significant prognostic factors. In conclusion, MI ≥50% and adnexal involvement are independent prognostic factors for RFS and DSS in G3EEC patients.

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Section: A B Cmentioning

confidence: 86%

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

Wang

Nan

et al. 2016

Oncology Letters

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“…Along with the tumor penetrated to the fat layer, the Nup88 was remarkably increased. It has been reported that in endometrial carcinoma, growing levels of Nup88 mRNA expression was correlated with the depth of myometrial invasion [4]. In our study, the levels of Nup88 in the pre-operative serum of CRC patients with advanced stage (Ⅲ±Ⅳ) were much higher than the earlier stage (Ⅰ±Ⅱ).…”

Section: Discussionmentioning

confidence: 41%

“…Nup88 has been shown in previous studies to be overexpressed in a wide variety of malignancies including gastroenteric carcinomas [3][4][5]. In our previous studies on tissues from CRC patients, Nup88 protein determined by immunohistochemistry was overexpressed in the primary tumor and lymph node metastasis of CRC compared to the normal colorectal mucosa, and the strong expression of Nup88 predicted a worse outcome in the patients [6][7].…”

Section: Introductionmentioning

confidence: 72%

Increased serum level of Nup88 protein is associated with the development of colorectal cancer

et al. 2011

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1 Increased serum level of Nup88 protein is associated with the development of colorectal cancer2 Abstract Nucleoporin88 (Nup88) has been shown to be overexpressed in a wide variety of malignancies including colorectal cancer (CRC). However, no study about serum Nup88 in human CRC was reported. Therefore, in this study, we investigated the level of serum Nup88 protein and its relationships with clinicopathological variables in CRC. The serum concentration of Nup88 protein was determined by a quantitative sandwich enzyme-linked immunosorbent assay (ELISA) in 118 pre-operative serum samples, 66 post-operative and 96 healthy controls. Among the patients, the levels of CEA (n=91) and CA19-9 (n=87) in the pre-operative serum were measured, and DNA sequencing was performed in 12 CRCs and 2 samples from non-cancerous colon tissue. In the same patients, the level of pre-operative serum Nup88 was significantly higher than the post-operative Nup88 (P=0.021).Furthermore, the level of pre-operative Nup88 was positively related to the depth of tumor invasion (P=0.002) and advanced stage (P=0.001). The level of pre-operative Nup88 in the left colon tended to be higher than that in the right colon and the rectum (P=0.063). DNA sequencing results showed that there were two single nucleotide polymorphism, distributed in exon 6 (NM_002532.3:c.1044G>A

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“…Several components of the nuclear periphery — lamins, LAP2 and emerin — have already been assessed as bio-markers in a wide range of cancer types (for example, see REFS 13,122–125) (TABLE 1). NUP88 was serendipi tously discovered as a cancer biomarker 126,127 , and has since been found in many studies to be overexpressed in malignant tissues 127–133 . More generally, lamins, certain nucleoporins and SENP1 have emerged in unbiased screens as biomarkers of interest for their change in levels found in cancer (for example, see REFS 45,134–136).…”

Section: Applying Knowledge Of the Nuclear Envelopementioning

confidence: 99%

The nuclear envelope environment and its cancer connections

2012

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Because of the association between aberrant nuclear structure and tumour grade, nuclear morphology is an indispensible criterion in the current pathological assessment of cancer. Components of the nuclear envelope environment have central roles in many aspects of cell function that affect tumour development and progression. As the roles of the nuclear envelope components, including nuclear pore complexes and nuclear lamina, are being deciphered in molecular detail there are opportunities to harness this knowledge for cancer therapeutics and biomarker development. In this Review, we summarize the progress that has been made in our understanding of the nuclear envelope and the implications of changes in this environment for cancer biology.

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Nup88 Expression is Associated With Myometrial Invasion in Endometrial Carcinoma

Abstract: From these results, it is concluded that Nup88 expression seems indeed to be associated with a distinct feature of tumor aggressiveness (myometrial invasion) in endometrial carcinoma and that larger studies are therefore probably worthwhile.

Cited by 16 publications

References 9 publications

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

Increased serum level of Nup88 protein is associated with the development of colorectal cancer

The nuclear envelope environment and its cancer connections

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