Background Nurse managers play a critical role in enhancing nursing and patient outcomes. Nurse managers’ behaviour and the clinical environment have been shown to affect nurses’ job satisfaction. In addition, leadership, managers’ support, and nurse-manager trust all improve the patient safety culture climate and reduce medication errors. However, hospital management and organisational support influence both manager and staff attitudes, which can affect care quality outcomes. This study aims to describe the relationships between nurse managers’ work content, nurses’ job satisfaction, patient satisfaction, and medication errors at the hospital unit level. Methods The questionnaire data were collected from nurse managers (n= 29), nursing staff (n=306), and patients (n=651) from 28 units across three Finnish acute care hospitals in year 2017. Analysis of covariance (ANCOVA) was used to estimate relationships between data from Nurse Managers’ Work Content Questionnaire, Kuopio University Hospital Job Satisfaction Scale, and Revised Humane Caring Scale subscales, along with medication errors reports. Results Multiple relationships were identified for components of nurse managers’ work content, nurses’ job satisfaction, patient satisfaction, and medication errors. How nurse managers divide their time between various responsibilities was shown to influence the patient satisfaction Outcomes subarea (p< .001), the Requiring factors of work subarea of nurses’ job satisfaction (p< .001), as well as medication errors (p< .001).Conclusions It would be recommendable for nurse managers to prioritise focusing on employee well-being, development, and communication. However, to be effective and beneficial, the work in each of these subareas must be well organised. The results demonstrate that nurse managers need to consciously balance their workloads to achieve better outcomes.