Nurses Are Everywhere: A Practical Perspective on the Surgical Team in Managing Postoperative Ileus

Saufl, Nancy M.; Strzyzewski, Nancy

doi:10.1016/j.jopan.2006.01.014

Journal of PeriAnesthesia Nursing

2006

DOI: 10.1016/j.jopan.2006.01.014

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Nurses Are Everywhere: A Practical Perspective on the Surgical Team in Managing Postoperative Ileus

Nancy M. Saufl

Nancy Strzyzewski²

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2009

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Cited by 2 publications

(1 citation statement)

References 17 publications

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“…In particular, questions about normal bowel function, home medications, need for laxative use, and history of constipation with surgery can be helpful. 4 If possible, performing the surgical procedure laparoscopically may decrease the incidence of POI. Postoperatively, the use of epidural analgesia and provision of stool softeners to patients receiving opioids may prevent the occurrence of constipation.…”

mentioning

confidence: 99%

Peripheral Opioid Receptor Antagonists for Postoperative Bowel Dysfunction

Ipema¹,

Golembiewski²

2009

Journal of PeriAnesthesia Nursing

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mentioning

confidence: 99%

Peripheral Opioid Receptor Antagonists for Postoperative Bowel Dysfunction

Ipema¹,

Golembiewski²

2009

Journal of PeriAnesthesia Nursing

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Peripherally Acting Mu-Opioid Receptor Antagonists and Postoperative Ileus: Mechanisms of Action and Clinical Applicability

Viscusi¹,

Gan²,

Leslie³

et al. 2009

Anesthesia &Amp; Analgesia

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Postoperative ileus (POI), a transient cessation of coordinated bowel function after surgery, is an important health care problem. The etiology of POI is multifactorial and related to both the surgical and anesthetic pathways chosen. Opioids used to manage surgical pain can exacerbate POI, delaying gastrointestinal (GI) recovery. Peripherally acting mu-opioid receptor (PAM-OR) antagonists are designed to mitigate the deleterious effects of opioids on GI motility. This new class is investigational for POI management with the goal of accelerating the recovery of upper and lower GI tract function after bowel resection. In this review, we summarize the mechanisms by which POI occurs and the role of opioids and opioid receptors in the enteric nervous system, discuss the mechanism of action of PAM-OR antagonists, and review clinical pharmacology and Phase II/III POI trial results of methylnaltrexone and alvimopan. Finally, the role of anesthesiologists in managing POI in the context of a multimodal approach is discussed.

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Nurses Are Everywhere: A Practical Perspective on the Surgical Team in Managing Postoperative Ileus

Cited by 2 publications

References 17 publications

Peripheral Opioid Receptor Antagonists for Postoperative Bowel Dysfunction

Peripheral Opioid Receptor Antagonists for Postoperative Bowel Dysfunction

Peripherally Acting Mu-Opioid Receptor Antagonists and Postoperative Ileus: Mechanisms of Action and Clinical Applicability

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