“…Notwithstanding the contents of the guideline, 1 the length of stay in situ is still debated. Recent literature [3][4][5][6][7][8] and clinical practice data 9 show the tendency to maintain the catheter over the prescribed 96 hours. This lack of guideline adherence seems to be supported by several factors: (a) for nurses, it is difficult to explain to and argue with the patients about the need to replace a properly functioning PIV catheter 4,9 ; (b) the replacement may have a negative impact, such as discomfort and pain, on patients 4 ; (c) the replacement might also increase the risk of infection, because each time skin integrity is breached, a potential portal for pathogens is provided 4 ; and (d) the recent systematic review made by Webster and colleagues 5 found no conclusive evidence in the need for catheter replacement every 72 to 96 hours.…”