Rapid Response Systems (RRS) improve patient outcomes at large medical centers. Little is known about how RRS are used in other medical settings. The purpose of this exploratory study was to describe RRS events at a long-term acute care hospital (LTACH). We conducted a retrospective review of 71 RRS event records at an urban 50-bed Midwestern LTACH. Measures included demographic data, triggering mechanisms, contextual factors, mechanism factors, and clinical outcomes. Of patients who experienced a RRS event, median age was 71 (62, 80) years; 52.1% were female; most ( n = 49, 69%) were “full code.” Most ( n = 41, 58%) events occurred during the daytime. The most common trigger was “mental status changes/unresponsiveness.” Registered nurses were the most frequent activator ( n = 19, 26.8%) and responders ( n = 63, 60.6%). Median duration of RRS events was 14 (6, 25) minutes. Most patients stabilized and their condition improved ( n = 54, 76.1%). RRS can be expanded and modified to the LTACH population.