“…We found fatigue, nausea, intestinal disorders and hand-foot syndrome to be the most common symptoms reported by next of kin. This is confirmed by other studies investigating patients (Aprile et al, 2008;Berger et al, 2010;Goldberg et al, 2007;Griffin-Sobel, 2006;Hallquist Viale and Sommers, 2007;Henry et al, 2008;Kearney et al, 2008). However, the next of kin reported that nausea worsened with every treatment, whereas other studies on patients, in contradiction, have found that nausea decreases after every treatment (Henry et al, 2008;Kearney et al, 2008).…”