Background: Illness behavior refers to the ways of perceiving, assessing, and managing specific symptoms by an individual. Objectives: The present study aims to investigate illness behavior during the COVID-19 outbreak among Afghan people. Methods: The study is a thematic analysis conducted between May and September 2020. Data were collected purposefully through semi-structured telephone interviews with 17 infected people from the cities of Kabul, Bamian, and Balkh in Afghanistan. Results: As the participants believed, the COVID-19 outbreak in their country was a socio-political rather than a medical phenomenon. In this situation, the health system is unable to meet medical needs, and patients creatively take care of themselves at home with exercise, local soups, and oxygen therapy if needed. There were four themes explored, including de-hospitalization, healthcare-seeking behavior, social stigma, and the role of media. Conclusions: The illness behavior regarding disease outbreaks is a social rather than a clinical phenomenon. It includes de-pharmaceuticalization perceptions and activities. Therefore, healthcare systems are recommended to pay attention to the socio-political dimensions of illness behavior during such outbreaks.