Objective: The vaccination of skilled nursing facility (SNF) staff is a critical component in the battle against COVID-19. Together, residents and staff constitute the single most vulnerable population in the pandemic. The health of these workers is completely entangled with the health of those they care for. Vaccination of SNF staff is key to increasing uptake of the vaccine, reducing health disparities, and reopening SNFs to visitors. Yet, as the vaccine rollout begins, some SNF staff are declining to be vaccinated. The purpose of this article is to describe reasons for COVID-19 vaccine hesitancy reported by staff of skilled nursing facilities and understand factors that could potentially reduce hesitancy. Design: Five virtual focus groups were conducted with staff of SNFs as part of a larger project to improve vaccine uptake. Setting and Participants: Focus groups with 58 staff members were conducted virtually using Zoom. Measures: Focus groups sought to elicit concerns, perspectives, and experiences related to COVID-19 testing and vaccination. Results: Our findings indicate that some SNF staff are hesitant to receive the COVID-19 vaccine. Reasons for this hesitancy include beliefs that the vaccine has been developed too fast and without sufficient testing; personal fears about pre-existing medical conditions, and more general distrust of the government. Conclusions and Implications: SNF staff indicate that seeing people like themselves receive the vaccination is more important than seeing public figures. We discuss the vaccination effort as a social enterprise and the need to develop long-term care provider-academic-community partnerships in response to COVID-19 and in expectation of future pandemics.Ó 2021 AMDA e The Society for Post-Acute and Long-Term Care Medicine.Coronavirus (COVID-19) has disproportionately affected skilled nursing facility (SNF) residents and staff in the United States, with the highest rates of infection and mortality in both groups. 1 Since the pandemic began, approximately 40% of all US coronavirus fatalities are in SNFs or similar long-term care facilities. One month before COVID-19 vaccine distribution began in the United States, an estimated 100,000 residents and staff at long-term care facilities had died with the virus, 2 likely an undercount. Despite efforts to control virus spread by locking down facilities and restricting access to outside visitors, 3 COVID-19 outbreaks in SNFs persist, largely due to unintentional asymptomatic transmission from exposed SNF staff who live in the larger community. 4,5 Vaccination of these workers is critical for several reasons. First, the vaccine protects staff personally and against compounding existing health disparities. SNF staff are often disadvantaged. Nursing assistants comprise 53% of the SNF workforce. More than 90% are women, 49% black or Latino, 44% live in low-income households, and 36% are uninsured or on public health care. 6 Thus, nursing assistants are among the most vulnerable groups at risk of contracting COVID-19 in the co...