Introduction Nurses are the largest users of hospital information systems in any health care system. Hence, collecting nurses ‘experiences and viewpoints about benefits of integrating IT into health care can help managers facilitate nurses’ adoption of IT. This study explored the experiences and viewpoints of nurses with IT integration into health care and their adoption of IT. Methods This study was conducted with a qualitative research approach. Participants included 14 nurses from four hospitals, affiliated to a large medical university, who were selected using a purposive sampling method. Data were collected through semi-structured interviews and analyzed using the conventional content analysis of Lundman and Graneheim. Results Six categories in the study reflected the nurses´ experiences and viewpoints about benefits of integrating IT into health care. These categories included improving the quality and efficiency of medical services and care, facilitating the communication management in the technological environment, improving information documentation, management, and monitoring, improving resource management, improving management performance and policymaking, and facilitating pathways of organizational and professional growth. Conclusions Understanding of nurses´ experiences and viewpoints about IT can contribute to the adoption, to overcome the barriers, and to develop appropriate strategies to orient nurses towards the benefits of IT in health care settings. Health care managers are recommended to investigate the experiences of nurses with IT in their hospitals and organize courses to orient hesitant nurses toward adopting IT.