This chapter presents the results of an integrative review and synthesis of the literature to identify the impact of the student response system (SRS) as a tool to enhance active learning in higher education. An integrated review was conducted using multiple databases, including CINAHL, ERIC, LWW Nursing and Health Professions Premier Collection, MEDLINE, ProQuest Education Journals and SAGE Journals. Related articles from 2008 to 2017 were reviewed systematically. Four broad search categories were used: "higher education", "student response system", "teaching and learning" and "active learning". A total of 302 articles were retrieved, followed by an in-depth review by screening each of them. Finally, 14 articles were selected. They were analysed using an inductive approach to extract statements for categorisation and synthesis. This review confirmed that there was limited empirical evidence to investigate the SRS as a tool in higher education. These articles were focused on descriptions of the use of the SRS in the aspects of questioning strategy, expectation, reward and feedback. This chapter provides an essential guide on SRS implementation to enhance active learning in higher education.