This study aimed to investigate the prevalence of Nomophobia and explore its connections with demographic variables and Religiosity, Spiritual Intelligence, Meaningfulness, and Satisfaction with Life, among undergraduate students in Ghana. The study employed a web-based cross-sectional survey design, encompassing n = 596 university students in Ghana. The results of this study demonstrated a significant negative nexus between students' Nomophobia, Religiosity, Spiritual Intelligence, and Meaningfulness (p < .05). Satisfaction with Life exhibited a positive correlation with Nomophobia. Furthermore, all the predictors collectively accounted for 76.6% of the total variance in Nomophobia, highlighting their substantial influence. Religion emerged as the most significant variable associated with Nomophobia. The study implies that promoting Religiosity, Spiritual Intelligence, and Meaningfulness can reduce Nomophobia in Ghanaian university students. It also stresses the importance of boosting overall student satisfaction and incorporating religious and spiritual aspects in Nomophobia interventions.