Nut and peanut butter consumption and the risk of lung cancer and its subtypes: A prospective cohort study

Nieuwenhuis, Lisette; Brandt, Piet A. van den

doi:10.1016/j.lungcan.2018.12.018

Cited by 16 publications

(7 citation statements)

References 34 publications

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“…The observed sex differences were also seen in previous analyses on nut consumption and cancer risk in the NLCS ( 50 ). One possible explanation might be differences in nut intake.…”

Section: Discussionsupporting

confidence: 81%

Nut and peanut butter intake and the risk of colorectal cancer and its anatomical and molecular subtypes: the Netherlands Cohort Study

Nieuwenhuis¹,

Simons

Weijenberg

et al. 2020

Carcinogenesis

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Nut intake has been associated with reduced total cancer-related mortality, but evidence for colorectal cancer (CRC) risk is inconclusive. We investigated the associations between nut and peanut butter intake and anatomical CRC subtypes. To account for molecular heterogeneity, associations between nut and peanut butter intake and colorectal tumors harboring APC, KRAS, or BRAF mutations, p53 overexpression, or microsatellite instability were examined in secondary analyses. In the NLCS (n=120852), lifestyle habits were measured with a questionnaire in 1986. After 20.3 years follow-up, 3567 CRC cases were included in case-cohort analyses. For the analyses of molecular CRC subtypes, 574 cases were included after 7.3 years follow-up. In categorical analyses, total nut intake was not significantly associated with CRC (HR(95%CI) 10+ g/day versus nonconsumers=0.94(0.78-1.15) in men; 0.96(0.75-1.22) in women). In restricted cubic spline analyses, significant nonlinear inverse associations with rectal cancer were observed for total nut, peanut, and peanut butter intake in women, and borderline significant nonlinear inverse associations for total nut and peanut intake in men. Regarding the molecular CRC subtypes, peanut butter intake was significantly associated with an increased risk of colorectal tumors that did not develop through the serrated neoplasia pathway in men (HR(95%CI) per 5 g/day increment=1.22(1.07-1.38)). Nut and peanut butter intake are nonlinearly inversely associated with rectal cancer risk in women. In men, nut intake is borderline significantly nonlinearly associated with a reduced rectal cancer risk. Peanut butter is associated with an increased risk of colorectal tumors that do not develop through the serrated neoplasia pathway in men.

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“…The observed sex differences were also seen in previous analyses on nut consumption and cancer risk in the NLCS ( 50 ). One possible explanation might be differences in nut intake.…”

Section: Discussionsupporting

confidence: 81%

Nut and peanut butter intake and the risk of colorectal cancer and its anatomical and molecular subtypes: the Netherlands Cohort Study

Nieuwenhuis¹,

Simons

Weijenberg

et al. 2020

Carcinogenesis

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“…Nut intake does not cause weight gain, but it improves body mass index and reduces the risk of obesity [6,17]. There has been a recent public increase in interest in the association between nut consumption and cancer [8,[18][19][20][21][22][23]. Recent studies have indicated a significant association between nut consumption and cancer risk and mortality [4,8].…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of the association between nut consumption and the risks of cancer incidence and cancer-specific mortality

Zhang

Dai²,

Zhou

et al. 2020

Aging

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Previous studies have indicated a correlation between nut intake and cancer risk in humans. This meta-analysis aimed to determine the relationship between nut consumption and the risks of cancer incidence and mortality. The PubMed, Embase, and Web of Science databases were searched up to August 2019. Relative risks and 95% confidence intervals were calculated using random-effects and fixed-effects models. We included 38 studies on nut consumption and cancer risk and 9 studies on cancer-specific mortality. Compared with no nut intake, nut intake was associated with a lower cancer risk (Relative Risk=0.90; 95% confidence interval, 0.86-0.94). Inverse associations were observed with colorectal cancer, gastric cancer, pancreatic cancer, and lung cancer in subgroup analyses. Tree nut consumption was found to reduce cancer risk (Relative Risk=0.88; 95% confidence interval, 0.79-0.99). Dose-response curves suggested that protective benefits against cancer increased with increased nut intake (P=0.005, P-nonlinearity=0.0414). An inverse correlation with cancer-specific mortality (Odd Ratio=0.90; 95% confidence interval, 0.88-0.92) was observed. In conclusion, nut consumption is inversely associated with the risks of cancer incidence and mortality; a higher intake is significantly associated with a lower cancer risk.

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“…Macadamia nut is a good source of tocopherols, tocotrienols, and squalene which can confer antioxidant and anticancer properties to consumers. Nieuwenhuisa and Brandt [166] conducted a large prospective cohort study and reported that total nut, tree nut, and peanut intake reduced the risk of small cell carcinoma in men.…”

Section: Cancermentioning

confidence: 99%

Nuts as Dietary Source of Fatty Acids and Micro Nutrients in Human Health

Pradhan¹,

Peter²,

Dileep³

2021

Nuts and Nut Products in Human Health and Nutrition

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In recent times, the Mediterranean diet plans are very popular because it has a lot of advantage in protecting from chronic health problems. Nuts are the integral part of the Mediterranean diet and advised to be incorporated in diet for health benefits. Both tree nuts and pea nut are good source of unsaturated fatty acids, soluble and insoluble fibers, good quantity of vitamins, minerals and phytochemicals with recognized benefits to human health. Due to life style disorders many chronic diseases are increasing in human beings. There are many epidemiological studies and research conducted on the relationship between consumption of nuts and chronic disease risks. This book chapter elaborately discusses about the nutritional composition of the nuts and their effect on cardiovascular disease, obesity, diabetes and cancer.

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Nut and peanut butter consumption and the risk of lung cancer and its subtypes: A prospective cohort study

Cited by 16 publications

References 34 publications

Nut and peanut butter intake and the risk of colorectal cancer and its anatomical and molecular subtypes: the Netherlands Cohort Study

Nut and peanut butter intake and the risk of colorectal cancer and its anatomical and molecular subtypes: the Netherlands Cohort Study

Meta-analysis of the association between nut consumption and the risks of cancer incidence and cancer-specific mortality

Nuts as Dietary Source of Fatty Acids and Micro Nutrients in Human Health

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