NUT Midline Carcinoma of the Lung, A Rare Form of Lung Cancer

Diagnosis, Treatment and Prognosis of Primary Pulmonary NUT Carcinoma: A Literature Review

“…This study evaluated 55 patients (36 men and 19 women) among the 35 articles [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ] with a mean age of 41.4 years (range, 6–82). The male to female ratio was approximately 1.89 to 1.…”

Radiotherapy play an important role in nut carcinoma: a case report

“…NUT carcinoma is a rare, poor differentiated, high lethal cancer which clinical feature as often occurred on the middle position of the body, and happened on from children to the old, no difference at gender, hard diagnosis, progressed fast, and no effective therapy, disaster ending 6,[11][12][13] . Pulmonary nut carcinoma is a special kind with worse prognosis [14][15][16][17][18] . Recent years, a lots of reports were studied.…”

Nuclear protein in testis carcinoma of the lung

“…However, pulmonary NUT carcinoma tends to grow very fast, aggravates local blood supply insufficiency, and is prone to necrosis, which may be a feature of pulmonary NUT carcinoma. Exiting research [ 31 , 38 , 39 , 45 , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] ] has shown that 96% of pulmonary NUT carcinomas develop distant metastasis, mainly bone metastases (70%) and lymph node metastases (50%), but liver, adrenal glands, skin, pleura, and other metastases are also likely to occur.…”

“…and Kagoya et al. [ 47 , 48 ] studies on mouse models as well as in vitro models revealed that BETi JQ1 could regulate the expression of the immune checkpoint ligand PD-L1 and is associated with increased anti-tumor cytotoxic T cells. Partial responses [ 73 , 74 ] were observed in 20% - 30% of patients treated with BET inhibitors in phase I trials.…”