2017
DOI: 10.1002/adfm.201703303
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Nutlin‐3a and Cytokine Co‐loaded Spermine‐Modified Acetalated Dextran Nanoparticles for Cancer Chemo‐Immunotherapy

Abstract: The combination of chemo-and immunotherapy represents one promising strategy to overcome the existent challenges in the present-day anticancer therapy. Here, spermine-modified acetalated dextran nanoparticles (Sp-AcDEX NPs), co-loaded with the non-genotoxic molecule Nutlin-3a (Nut3a), and the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), are developed to induce cancer cell death and create a specific antitumor immune response. These polymeric NPs release Nut3a in a pH dependent fashion an… Show more

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Cited by 69 publications
(51 citation statements)
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References 69 publications
(70 reference statements)
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“…Moreover, the BZL@LNPs-DSS showed a superior efficacy than the BZL@LNPs-iRGD, as for MDA-MB-231 cell line. As expected, the antiproliferative effect of the BZL@LNPs was more pronounced toward the 2D cell model, Small 2019, 15,1901427…”
Section: In Vitro Antiproliferative Studiessupporting
confidence: 78%
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“…Moreover, the BZL@LNPs-DSS showed a superior efficacy than the BZL@LNPs-iRGD, as for MDA-MB-231 cell line. As expected, the antiproliferative effect of the BZL@LNPs was more pronounced toward the 2D cell model, Small 2019, 15,1901427…”
Section: In Vitro Antiproliferative Studiessupporting
confidence: 78%
“…As for the size distribution (Figure 2a), the prepared LNPs and BZL@LNPs before and after functionalization exhibited PDI values lower than 0.20, suggesting a moderate dispersity of the LNPs. The size distribution and morphology of the LNPs was also verified by transmission electron microscopy (TEM, Figure 2b), where the particles showed an average size and moderate dispersity similar to the values found by Small 2019, 15,1901427 DLS. Furthermore, the LNPs showed symmetric and spherical shape, due to the suitable interaction between the lignin and water during the process of solvent exchange.…”
Section: Characterization Of the Peptide-functionalized Lnpssupporting
confidence: 73%
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