Nutraceutical potential and hypolipidemic properties of the volatiles from the edible leaves of<i>Peperomia maculosa</i>

Villa‐Ruano, Nemesio; Pacheco‐Hernández, Yesenia; Zarate-Reyes, José Alejo; Becerra‐Martínez, Elvia; Lozoya‐Gloria, Edmundo; Durán, Ramiro Cruz

doi:10.1111/jfbc.12650

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…Conocimiento etnobotánico Xalaktsu kuksasan, como se llama en Totonaco a Peperomia peltilimba en la comunidad de Chipahuatlan (Olintla, Puebla, México) se identifica como tequelite chico por el tamaño de sus hojas, en comparación con P. maculosa que presenta hojas más grandes (UNIBIO, 2010;Villa-Ruano et al, 2018). En observaciones de campo se registraron hojas de tequelite chico con 4 a 9 cm de largo y entre 4 y 6 cm de ancho.…”

Section: Resultados Y Discusiónunclassified

Conocimiento tradicional sobre el uso y conservación del tequelite chico en Chipahuatlan, Olintla, Puebla.

Hernández

Franco

Tlatelpa

et al. 2023

ASYD

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El tequelite chico (Peperomia peltilimba C. DC. ex Trelease) es una planta nativa y silvestre de México, considerada vulnerable a la extinción. El objetivo de este estudio fue documentar el conocimiento y la percepción sobre la conservación y el uso del tequelite chico en la comunidad totonaca de Chipahuatlan, Olintla, en el estado de Puebla (México). Se aplicaron 53 entrevistas semiestructuradas a una muestra representativa de la población; se consideró como universo al número de familias. La entrevista estuvo conformada por las secciones, conocimiento de la especie, conservación, comercialización, usos y beneficios. Se realizaron recorridos en el hábitat natural de la especie para documentar flora y fauna acompañantes. Los resultados indicaron que los tallos y hojas del tequelite chico se utilizan para la elaboración de alimentos tradicionales como mole, caldos, tamales y frijoles hervidos con o sin ajonjolí. La especie se obtiene a través de su hábitat natural y en tianguis locales, aunque algunas familias tienen plantas en sus traspatios. Los conocimientos tradicionales sobre el tequelite chico están relacionados con la flora y la fauna, se aprovechan solo las plantas más desarrolladas y se conservan las que presentan brotes o inflorescencias. Se identificó interés por conservar este recurso debido a su importancia cultural y económica; aunque su valor comercial es bajo, representa un ingreso adicional para las familias que se dedican a su recolección. Estos resultados son una aproximación al conocimiento totonaca y su percepción en torno a la conservación y el aprovechamiento del tequelite chico.

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Section: Resultados Y Discusiónunclassified

Conocimiento tradicional sobre el uso y conservación del tequelite chico en Chipahuatlan, Olintla, Puebla.

Hernández

Franco

Tlatelpa

et al. 2023

ASYD

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“…These procedures were basically performed in accordance with Villa‐Ruano et al [38] . Male ICR mice (eight weeks old; 30 g) were maintained for one week under controlled temperature (25 °C) and humidity (50 %) in 12 h light and 12 h darkness prior to experimentation.…”

Section: Methodsmentioning

confidence: 99%

“…These procedures were basically performed in accordance with Villa-Ruano et al [38] Male ICR mice (eight weeks old; 30 g) were maintained for one week under controlled temperature (25 °C) and humidity (50 %) in 12 h light and 12 h darkness prior to experimentation. Considering that male mice have lower hormone fluctuation than female mice, this study was exclusively performed with the first group of animals.…”

Section: In Vivo Anti-hyperlipidemic Assaysmentioning

confidence: 99%

Anthocyanins of Hierbamora (Solanum nigrescens): Revealing their Nutraceutical Potential for Controlling Hypertriglyceridemia and Helicobacter pylori Viability

Pacheco‐Hernández,

Lozoya‐Gloria,

Cruz‐Durán

et al. 2023

Chemistry & Biodiversity

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We present the inhibitory properties of the Solanum nigrescens anthocyanin fraction (SNAF) and its major constituents on alpha‐glucosidase (AG), pancreatic lipase (PL), HMG‐CoA reductase, and ornithine decarboxylase (ODC). The effect of SNAF was simultaneously evaluated in ICR male mice exposed to triglyceride charge test (TCT). HPLC‐MS profiling revealed the presence cyanidin‐3‐O‐rutinoside‐5‐glucoside (CRG), delphinidin‐3‐(p‐coumaroyl)‐rutinoside‐5‐glucoside (DCRG), and petunidin‐3‐(cis‐p‐coumaroyl)‐rutinoside‐5‐glucoside (PCRG) as major constituents of the fraction. SNAF, CRG, and specially PCRG, induced strong non‐competitive inhibition on PL (IC50, 33‐86 µg mL‐1). The results of TCT confirmed their capacity to ameliorate (p < 0.001) hypertriglyceridemia during postprandial and interdigestive stages. SNAF, CRG, DCRG, and PCRG caused negligible growth inhibition (MIC > 600 µg mL‐1) on beneficial bacteria whereas SNAF and DCRG exerted inhibitory activity on Helicobacter pylori ATCC25922 (MIC,187‐64 µg mL‐1). Additional exploration revealed that SNAF and DCRG produced non‐competitive activity on H. pylori urease, which facilitates bacterial growth under acidic conditions.

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“…Blood samples were extracted from the tail vein at 0, 1.5, 3, 4.5, and 6 h and stored in heparin tubes for immediate analysis. Blood plasma was obtained by centrifugation at 3500 g and then subjected to triglyceride quantification using the Spinreact® kit in accordance with Villa-Ruano et al (2018).…”

Section: Evaluation Of Rv He and Ca On Postprandial Triglyceride Accu...mentioning

confidence: 99%

Comparative effect of resveratrol, carnosic acid and hernandulcin on target enzymes and biochemical markers linked to carbohydrate and lipid metabolism in mice

Villa-Ruano,

Ramírez-García,

Landeta-Cortés

et al. 2023

Emir J Food Agric

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Resveratrol (RV), carnosic acid (CA) and hernandulcin (HE; a non-caloric sweetener) are envisioned as promising nutraceuticals to designnew functional foods for improving lipid and carbohydrate metabolism. This study aimed to investigate the in vitro inhibitory effectof these molecules on specific enzyme targets and their capacity to improve distinctive markers associated to carbohydrate and lipidmetabolism in murine model. The enzymes explored were alpha-amylase, alpha-glucosidase, and pancreatic lipase whereas ICR malemice were used for in vivo testing. Saturation curves (10-200 µM mL-1) and Lineweaver-Burk regressions suggested that RV, CA andHE exerts non-competitive inhibition on pancreatic lipase, alpha-glucosidase and alpha-amylase but, CA produced a strong competitiveactivity on alpha-amylase. RV was more effective to inhibit alpha-glucosidase (IC50, 22.1 µM) whereas CA was the most effective toinhibit both alpha-amylase (IC50, 11.7 µM) and pancreatic lipase (IC50, 31.5 µM). The effects of the oral administration of RV (300 mg/kg) HE (100 mg/kg) and CA (100 mg/kg) as well as the simultaneous administration of the three compounds at the same concentration was also explored in normoglycemic and diabetic mice. In addition, the prolonged administration of these substances combined with hypercaloric/atherogenic diet for 30 days was performed. Our results revealed a clear modulatory activity in both postprandial glucose and triglyceride levels as well an improvement in biochemical markers of mice treated with hypercaloric/atherogenic diet. The administration of HE produced a notable change (p < 0.01) in postprandial glucose assimilation at 60 min post-treatment in diabetic mice, whereas the other two compounds exerted a stronger depletion of glucose levels from 30 to 120 min post-treatment. A similar trend was recorded by RV and CA in postprandial triglyceride content, however, the latter compound was more effective (p < 0.05) at lower doses than RV. The simultaneous administration of the three compounds produced a significant improvement (p < 0.01) in biochemical parameters associated to carbohydrate (insulin and glucose) and lipid metabolism (total cholesterol, LDL-c, HDL-c, triglycerides, leptin, and adiponectin).Outstandingly, the mixture of the three compounds was more effective (p < 0.01) than the administration of sole compounds to amelioratethe side effects of the hypercaloric/atherogenic diet. Finally, the body weight of treated mice significantly decreased (from 5 to 20%; p < 0.05) in comparison with mice only fed with hypercaloric/atherogenic diet. Our results suggest that mixtures of RV, HE and CA may work better than their sole administration in mice and part of their biological activity could be associated with their inhibitory properties on the enzyme targets evaluated in this investigation. Keywords: Carnosic acid; Hernandulcin; Resveratrol; Hypoglycemic; Hypolipidemic; Murine model; Target enzymes

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Nutraceutical potential and hypolipidemic properties of the volatiles from the edible leaves ofPeperomia maculosa

Cited by 8 publications

References 20 publications

Conocimiento tradicional sobre el uso y conservación del tequelite chico en Chipahuatlan, Olintla, Puebla.

Conocimiento tradicional sobre el uso y conservación del tequelite chico en Chipahuatlan, Olintla, Puebla.

Anthocyanins of Hierbamora (Solanum nigrescens): Revealing their Nutraceutical Potential for Controlling Hypertriglyceridemia and Helicobacter pylori Viability

Comparative effect of resveratrol, carnosic acid and hernandulcin on target enzymes and biochemical markers linked to carbohydrate and lipid metabolism in mice

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