Nutraceutical potential of Corylus avellana daily supplements for obesity and related dysmetabolism

Mollica, Adriano; Zengin, Gökhan; Stefanucci, Azzurra; Ferrante, Claudio; Menghini, Luigi; Orlando, Giustino; Brunetti, Luigi; Locatelli, Marcello; Dimmito, Marilisa Pia; Novellino, Ettore; Wakeel, Olayemi Kamoru; Ogundeji, M.O.; Onaolapo, Adejoke Yetunde; Onaolapo, Olakunle James

doi:10.1016/j.jff.2018.06.016

Cited by 64 publications

(29 citation statements)

References 75 publications

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“…In recent years, plant extracts have received great interest in the academic community and in the food industry (Ertas, Boga et al, ; Mollica et al, ). With the introduction of herbal medicine as an alternative form of health, screening of medicinal plants for bioactive compounds is becoming increasingly important.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and biological investigations on twoNepetaspecies:Nepeta heliotropifoliaandN. congestasubsp.cryptantha

et al. 2019

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In the present study, the essential oil and aroma compositions of Nepeta heliotropifolia (NH) and N. congesta subsp. cryptantha (NC) were determined by gas chromatography-mass spectrometry (GC-MS) and gas chromatography-flame ionization detector (GC/FID), and their phenolic compounds by liquid chromatography-tandem mass spectrometry (LC-MS/MS). In addition, antioxidant, cytotoxic, anticholinesterase, urease, and tyrosinase activities of essential oils obtained from NH and NC aerial parts and ethanol extracts prepared from different parts of NH and NC were investigated. The major constituent of water-distilled essential oils was found to be germacrene D (36.7% and 38.5%, respectively), and their main aroma component was eucalyptol (48.0% and 24.7%, respectively). Among the studied parts of NH and NC, their flowers extracts were found to be the richest in phenolic compounds and in which the most abundant compound was rosmarinic acid (8,909.91 and 4,317.20 μg/g, respectively). NH and NC flower extracts exhibited also strong antioxidant activity in DPPH, ABTS, and CUPRAC assays. Among the tested samples, NH essential oil indicated the best cytotoxic effect against PDF, HT-29, and MCF-7 (IC 50 52.34, 25.89, and 44.70 μg/ml, respectively), and the highest butyrylcholinesterase (77.21 ± 1.12% inhibition) and moderate acetylcholinesterase (41.36 ± 0.69% inhibition) inhibitory activities. Practical applicationsThis is the first report on the essential oil and aroma compositions, the phenolic compounds, the antioxidant with total phenolic and flavonoid contents, cytotoxic, anticholinesterase, urease, and tyrosinase activities of Nepeta heliotropifolia and N. congesta subsp. cryptantha, except for their essential oil compositions. The reported results suggested that Nepeta heliotropifolia and N. congesta subsp. cryptantha flowers being rich in rosmarinic acid and having strong antioxidant potential, and NH essential oil possessing significant cytotoxic and butyrylcholinesterase inhibitory effect could be source for nutraceutical, food, and drug industries. K E Y W O R D Saroma, biological activities, essential oil, LC-MS/MS, Nepeta, phenolic compound 2 of 12 | AKDENIZ Et Al.

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Section: Introductionmentioning

confidence: 99%

Phytochemical and biological investigations on twoNepetaspecies:Nepeta heliotropifoliaandN. congestasubsp.cryptantha

et al. 2019

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“…4). Epicatechin gallate (53), epigallocatechin gallate (54), and gallocatechin gallate (55) were described in the hazelnut kernel [33], and epicatechin gallate (53) was identified in the skins [24].…”

Section: Tannins and Proanthocyanidinsmentioning

confidence: 99%

“…The total antioxidant activities of the extracts obtained from hazelnut kernels, natural and roasted, with or without skins, differing for geographical origins, varieties, and storage conditions, have been measured [7,17,27,[49][50][51][52][53][54][55][56][57][58]. Mostly, no statistical differences in total antioxidant activity have been observed among samples of unroasted and roasted kernels without skins; the thermal processing had a light negative trend in antioxidant efficacy mainly due to the absence of skins [1,27,50,52,59].…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…With the aim to examine the potential nutraceutical benefits of hazelnut in Alzheimerʼs neurodegenerative disease, the in vitro enzyme inhibition properties of hazelnut samples grown in 2 regions, Piedmont in Italy and the Black Sea region in Turkey, along with the possible neuroprotective effects of both hazelnut varieties on catecholamine levels in rat cerebral cortical specimens challenged with amyloid β-peptide by ex vivo experiments were evaluated [53]. In particular, in the in vitro enzyme inhibition assays, carried out against cholinesterase, tyrosinase, amylase and glucosidase and performed in agreement with the enzyme inhibitory theory considered as one of the most useful therapeutic ways for managing global health problems including Alzheimerʼs disease, Turkish hazelnut methanol extracts had a more considerable enzyme inhibitory potential than Italian ones.…”

Section: Protective Effect Against Neurochemical Alterations In Alzhementioning

confidence: 99%

“…The reduction in tissue levels of dopamine was related to increased release as well as to the stimulatory effects on dopamine release induced by ascorbic acid, which is significantly present in hazelnuts and that could enhance the synthesis of norepinephrine from dopamine. The authors also hypothesize that increased levels of norepinephrine can be linked to the high hazelnut polyphenolic and flavonoid content that could be responsible of the blunting effect on norepinephrine levels induced by amyloid β-peptide treatment, ex vivo, and also that could induce norepinephrine signaling stimulation, mitigating effects against age-related cognitive and motor decline [53,70].…”

Section: Protective Effect Against Neurochemical Alterations In Alzhementioning

confidence: 99%

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Plant Specialized Metabolites in Hazelnut (Corylus avellana) Kernel and Byproducts: An Update on Chemistry, Biological Activity, and Analytical Aspects

et al. 2019

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Corylus avellana (hazelnut) is one of the most popular tree nuts on a worldwide basis. The main products of C. avellana are kernels, a nutritious food, with a high content of healthy lipids, contained in a hard shell. In recent years, along with the ongoing research carried out on hazelnut kernels, a growing interest has been addressed to the hazelnut byproducts including hazelnut skin, hazelnut hard shell, and hazelnut green leafy cover as well as hazelnut tree leaf. These byproducts deriving from the roasting, cracking, shelling/hulling, and harvesting processes have been found as a source of “phytochemicals” with biological activity. The aim of this review is to provide a comprehensive and critical update on the chemistry and biological activity of specialized metabolites occurring in hazelnut kernels and byproducts. Phenolics are the most abundant phytochemicals not only in the kernels, but also in other processing byproducts. Attention has been also devoted to taxane derivatives isolated from C. avellana leaves. An overview on the biological activity, mainly antioxidant, antiproliferative, and antimicrobial along with less common biological effects, has been provided, contributing to highlight C. avellana as a source of bioactive phytochemicals with the potential to exert beneficial effects on human health. Finally, analytical techniques for the quali-quantitative analysis of specialized metabolites occurring in the different parts of C. avellana have been reviewed.

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Functional Nutraceuticals

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2022

Handbook of Nutraceuticals and Natural Products

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Nutraceutical potential of Corylus avellana daily supplements for obesity and related dysmetabolism

Cited by 64 publications

References 75 publications

Phytochemical and biological investigations on twoNepetaspecies:Nepeta heliotropifoliaandN. congestasubsp.cryptantha

Phytochemical and biological investigations on twoNepetaspecies:Nepeta heliotropifoliaandN. congestasubsp.cryptantha

Plant Specialized Metabolites in Hazelnut (Corylus avellana) Kernel and Byproducts: An Update on Chemistry, Biological Activity, and Analytical Aspects

Functional Nutraceuticals

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