Nutraceutical Potential of Vitexin: A Flavone Glycoside

Abstract

Vitexin is an apigenin flavone glycoside and it is extensively present in numerous edible and medicinal plants. It is considered as important as other flavonoids. It possessed a variety of biological properties, including anti-oxidation, anti-inflammation, anticancer, neuron-protective, cardio-protective, hepatopancreatic protective effects. Other reported health relevant effects, includes fat reduction and glucose metabolism. The possible mechanism of protective effect through activation or inhibition of the different signaling pathways like AMPKa, Nrf-2, mTOR, PUMA, MMP, PARP, JNK, p38, Bcl-2/Bax ratio etc. The molecular targets of vitexin are very critical to utilize its potential effect as emerging chemopreventive and chemotherapeutic agent.

Development and Characterization of Chitosan-Based Spray-Dried Solid Dispersions of Apigenin: 3D Printed Shell-Pill for Improved Efficacy of Model Flavonoid

“…AGN has been shown to have antiinflammatory properties by inhibiting the activity of cyclooxygenases (COX) and lipoxygenases (LOX), enzymes involved in the production of prostaglandins and leukotrienes inflammatory molecules and also inhibit the activation of nuclear factor-kappa B (NF-κB), thereby reducing chronic, necrotic and immune regulated inflammation. It's a body's response to injury or infection, but chronic inflammation has been linked to heart disease, 3 of 21 diabetes, and cancer conditions [16], [17]. AGN acts as an anti-cancer agent by regulating the signaling pathways involved in cell cycle progression, angiogenesis, and metastasis, thereby inhibiting the growth of cancer cells, including breast, prostate, colon, lung cancer cells, and reducing the risk of certain types of cancer.…”

Effect of biotic and abiotic factors on the content of flavonoids in leaves of Passiflora sp. L.: A systematic review

“…Fertilizantes minerales El estado nutricional de las plantas tiene un efecto directo sobre el contenido de flavonoides (Deng et al, 2019). La disponibilidad de nitrógeno en la planta genera competencia entre las rutas biosintéticas de proteínas y compuestos fenólicos, fenilpropanoides y derivados como flavonoides, taninos y lignina (Haukioja et al, 1998;Taiz et al, 2015;Ranjan et al, 2023). Mendonça et al (2008), encontraron un aumento del 46% en el contenido de vitexina en plantas cultivadas en suelo con deficiencia del elemento.…”