Nutraceutical Properties of Milk Fat Globular Membrane

Hintze, Korry; Snow, Dallin; Burtenshaw, Ian; Ward, Robert E.

doi:10.5772/16722

Cited by 2 publications

(1 citation statement)

References 73 publications

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“…Lipids in milk and dairy products are known to be rich sources of sphingolipids, phospholipids and glycolipids. Milk lipids exist in the form of spherical entities, approximately 4-5 lm in diameter, called milk fat globules, surrounded by a membrane known as the milk fat globule membrane (MFGM) [1,2]. They are delivered through the MFGM system and perform various physiological activities [3].…”

Section: Introductionmentioning

confidence: 99%

Sphingolipid identification and skin barrier recovery capacity of a milk sphingolipid‐enriched fraction (MSEF) from buttermilk powder

Lee

Kim

et al. 2020

Intern J of Cosmetic Sci

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OBJECTIVE: In this study, we isolated the milk sphingolipid-enriched fraction (MSEF) of sweet buttermilk powder and conducted a clinical trial for evaluating its efficacy in skin barrier recovery. METHODS: Milk sphingolipid-enriched fraction was isolated via solvent extraction of buttermilk powder, and further concentrated by removing the phospholipids and neutral lipids. A cream containing 1% MSEF was used during clinical trials to assess for water holding and skin barrier recovery capacities. RESULTS: The main components of the MSEF were sphingomyelin, glucosylceramide and lactosylceramide, confirmed by TLC, HPLC, MS and NMR. The MSEF cream-treated group had a significantly higher (P < 0.05) water holding capacity, compared with the base cream (vehicle) group. Compared with that in the base cream group, transepidermal water loss (TEWL) recovery increased in the presence of the sphingolipid-containing MSEF cream (MSEF group), with a significant difference (P < 0.05) recorded on day 14. CONCLUSION: The MSEF cream contributed to improving the water holding capacity and skin barrier recovery of damaged skin. Therefore, sphingolipid-containing MSEF can be useful for strengthening or repairing skin barrier function. strength, and gene mutations or polymorphisms in ceramide biosynthesis affect skin barrier function [10].

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Section: Introductionmentioning

confidence: 99%

Sphingolipid identification and skin barrier recovery capacity of a milk sphingolipid‐enriched fraction (MSEF) from buttermilk powder

Lee

Kim

et al. 2020

Intern J of Cosmetic Sci

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In Vitro and In Vivo Anti-inflammatory Activity of Bovine Milkfat Globule (MFGM)-derived Complex Lipid Fractions

et al. 2020

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Numerous health related properties have been reported for bovine milk fat globule membrane (MFGM) and its components. Here we present novel data on the in vitro and in vivo anti-inflammatory activity of various MFGM preparations which confirm and extend the concept of MFGM as a dietary anti-inflammatory agent. Cell-based assays were used to test the ability of MFGM preparations to modulate levels of the inflammatory mediators IL-1β, nitric oxide, superoxide anion, cyclo-oxygenase-2, and neutrophil elastase. In rat models of arthritis, using MFGM fractions as dietary interventions, the phospholipid-enriched MFGM isolates were effective in reducing adjuvant-induced paw swelling while there was a tendency for the ganglioside-enriched isolate to reduce carrageenan-induced rat paw oedema. These results indicate that the anti-inflammatory activity of MFGM, rather than residing in a single component, is contributed to by an array of components acting in concert against various inflammatory targets. This confirms the potential of MFGM as a nutritional intervention for the mitigation of chronic and acute inflammatory conditions.

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Nutraceutical Properties of Milk Fat Globular Membrane

Cited by 2 publications

References 73 publications

Sphingolipid identification and skin barrier recovery capacity of a milk sphingolipid‐enriched fraction (MSEF) from buttermilk powder

Sphingolipid identification and skin barrier recovery capacity of a milk sphingolipid‐enriched fraction (MSEF) from buttermilk powder

In Vitro and In Vivo Anti-inflammatory Activity of Bovine Milkfat Globule (MFGM)-derived Complex Lipid Fractions

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