Nutraceutical regulation of miRNAs involved in neurodegenerative diseases and brain cancers

Ghosh, Souvik; Kumar, Viney; Mukherjee, Haimanti; Lahiri, Debrupa; Roy, Partha

doi:10.1016/j.heliyon.2021.e07262

Cited by 10 publications

(5 citation statements)

References 236 publications

(311 reference statements)

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“…MiRNAs have been proposed as potential biomarkers for disease ( Ghosh et al, 2021 ). Currently, CTE can only be diagnosed at autopsy and ALS is typically diagnosed after motor functions have declined.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis

et al. 2022

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Repetitive head impacts (RHI) and traumatic brain injuries are risk factors for the neurodegenerative diseases chronic traumatic encephalopathy (CTE) and amyotrophic lateral sclerosis (ALS). ALS and CTE are distinct disorders, yet in some instances, share pathology, affect similar brain regions, and occur together. The pathways involved and biomarkers for diagnosis of both diseases are largely unknown. MicroRNAs (miRNAs) involved in gene regulation may be altered in neurodegeneration and be useful as stable biomarkers. Thus, we set out to determine associations between miRNA levels and disease state within the prefrontal cortex in a group of brain donors with CTE, ALS, CTE + ALS and controls. Of 47 miRNAs previously implicated in neurological disease and tested here, 28 (60%) were significantly different between pathology groups. Of these, 21 (75%) were upregulated in both ALS and CTE, including miRNAs involved in inflammatory, apoptotic, and cell growth/differentiation pathways. The most significant change occurred in miR-10b, which was significantly increased in ALS, but not CTE or CTE + ALS. Overall, we found patterns of miRNA expression that are common and unique to CTE and ALS and that suggest shared and distinct mechanisms of pathogenesis.

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Section: Discussionmentioning

confidence: 99%

MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis

et al. 2022

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“…Studies have shown that nutritional components and nutraceuticals can control the activity of miRNAs that have a role in age-related disorders. This suggests that they could be used as potential treatments ( Ghosh et al, 2021 ).…”

Section: Implications For Prevention and Treatment Of Age-related Dis...mentioning

confidence: 99%

“…The gene expression patterns linked to aging and age-related disorders can be influenced by foods such as macronutrients, micronutrients, and trace minerals, which in turn can change miRNA profiles ( Beckett et al, 2014 ; Quintanilha et al, 2017b ). In addition, nutraceuticals have demonstrated potential as treatment methods for age-related diseases by altering miRNA expression ( Alnuqaydan, 2020 ; Ghosh et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies

Salama,

Eissa,

Doghish

et al. 2024

Front. Aging

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MicroRNAs (miRNAs) are short RNA molecules that are not involved in coding for proteins. They have a significant function in regulating gene expression after the process of transcription. Their participation in several biological processes has rendered them appealing subjects for investigating age-related disorders. Increasing data indicates that miRNAs can be influenced by dietary variables, such as macronutrients, micronutrients, trace minerals, and nutraceuticals. This review examines the influence of dietary factors and nutraceuticals on the regulation of miRNA in relation to the process of aging. We examine the present comprehension of miRNA disruption in age-related illnesses and emphasize the possibility of dietary manipulation as a means of prevention or treatment. Consolidating animal and human research is essential to validate the significance of dietary miRNA control in living organisms, despite the abundance of information already provided by several studies. This review elucidates the complex interaction among miRNAs, nutrition, and aging, offering valuable insights into promising areas for further research and potential therapies for age-related disorders.

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“…Brain tumours typically have a poor prognosis with an average life expectancy of approximately one year [75,76]. Among brain cancer types, glioblastoma multiforme is a common tumour [77], with a mean survival rate of ~ 3.3% at three years post-diagnosis [77,78]. Brain cancers have traditionally been treated with a surgical procedure followed by systemic chemotherapy, but these are limited due to the effects on the brain and severe toxicity.…”

Section: Brain Cancermentioning

confidence: 99%

TPGS Decorated Liposomes as Multifunctional Nano-Delivery Systems

Farooq

Trevaskis

2022

Pharm Res

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Liposomes are sphere-shaped vesicles that can capture therapeutics either in the outer phospholipid bilayer or inner aqueous core. Liposomes, especially when surface-modified with functional materials, have been used to achieve many benefits in drug delivery, including improving drug solubility, oral bioavailability, pharmacokinetics, and delivery to disease target sites such as cancers. Among the functional materials used to modify the surface of liposomes, the FDA-approved non-ionic surfactant D-alpha-tocopheryl polyethylene glycol succinate (TPGS) is increasingly being applied due to its biocompatibility, lack of toxicity, applicability to various administration routes and ability to enhance solubilization, stability, penetration and overall pharmacokinetics. TPGS decorated liposomes are emerging as a promising drug delivery system for various diseases and are expected to enter the market in the coming years. In this review article, we focus on the multifunctional properties of TPGS-coated liposomes and their beneficial therapeutic applications, including for oral drug delivery, vaccine delivery, ocular administration, and the treatment of various cancers. We also suggest future directions to optimise the manufacture and performance of TPGS liposomes and, thus, the delivery and effect of encapsulated diagnostics and therapeutics.

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Nutraceutical regulation of miRNAs involved in neurodegenerative diseases and brain cancers

Cited by 10 publications

References 236 publications

MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis

MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis

Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies

TPGS Decorated Liposomes as Multifunctional Nano-Delivery Systems

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