Nutraceutical with a promising oral anticancer effect: in vitro study on apricot oil extract

Abstract

Background One of the major threats to human health is malignancy. Treatment regimens usually followed by either chemo or radiotherapy have a wide range of collateral unwanted side effects. Scientists seek alternatives with less or no adverse consequences. Nutraceuticals possess disease-modifying implications in medicine related to Alzheimer’s, cardiovascular, Parkinson’s diseases and malignancy. Apricot oil extract is one such nutraceutical. Its active component is amygdalin, known also as vitamin B.17 or laetrile. It is found in a wide range of vegetable species. Amygdalin is found in high concentration in the kernels of rosaceous fruits such as bitter nuts and apricot kernels. Amygdalin is an aromatic cyanogenic component with a glycoside group. It has a diverse effect on different systems and organs of the body. Recently, it has shown an anticancer potential as it can decompose carcinogenic elements found in the body and kill malignant cells, so it results in cancer growth inhibition. There is a great debate related to the cyanide toxicity of amygdalin. The presented study aims to evaluate apricot oil extract’s impact on squamous cell carcinoma of the tongue, HNO97, while testing its safety on non-tumorigenic oral epithelial cells. Results HNO97 cell line viability was markedly decreased. This may be induced by the upregulation of autophagy, apoptosis enhancement as well as cell cycle arrest. Cancer cell migration was also decreased. Apricot oil caused no significant inhibition of normal OEC viability in low doses. Conclusions Apricot oil extract from apricot kernel had a notably antitumorigenic impact on oral cancer cells. It may be later subjected to pre- as well as clinical trials.

Organ-on-Chip: Advancing Nutraceutical Testing for Improved Health Outcomes

“…OOC models can be utilized to investigate the interactions between nutraceuticals and relevant cellular targets to study the target engagement, modulation of signaling pathways, and downstream cellular responses. After target identification, nutraceutical compounds undergo efficacy screening and optimization. − OOC-based safety assessment provides insights into the potential adverse effects and helps guide the selection of safe nutraceutical candidates for further development. OOC models can be utilized to study the absorption, distribution, metabolism, and excretion (ADME) properties of nutraceuticals.…”

“…This involves identifying suitable materials, establishing quality control measures, and optimizing the fabrication processes to ensure consistent and reliable production of OOC devices. Regulatory compliance is crucial to ensure the safe and effective use of OOC technology for nutraceutical testing regulations, i.e., the Food and Drug Administration (FDA) in the United States or the European Medicines Agency (EMA) in Europe may classify OOC platforms as medical devices or in vitro diagnostics. − …”

“…After target identification, nutraceutical compounds undergo efficacy screening and optimization. 119 − 121 OOC-based safety assessment provides insights into the potential adverse effects and helps guide the selection of safe nutraceutical candidates for further development. OOC models can be utilized to study the absorption, distribution, metabolism, and excretion (ADME) properties of nutraceuticals.…”