Nutraceuticals: A Promising Therapeutic Approach in Ophthalmology

Castro-Castañeda, Carlos Rodrigo; Altamirano-Lamarque, Francisco; Ortega-Macías, Alan Gabriel; Cruz-Pavlovich, Francisco J. Santa; Rosa, Alejandro Gonzalez-De la; Armendáriz‐Borunda, Juan; Santos, Arturo; Navarro-Partida, José

doi:10.3390/nu14235014

Cited by 17 publications

(14 citation statements)

References 249 publications

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“…Investigating nutraceuticals as a preventive or complementary strategy for SANS management reflects a holistic approach to astronaut health. Nutraceuticals aim to address nutritional deficiencies and enhance ocular resilience, contributing to preventing and managing SANSrelated ocular changes [50].…”

Section: Potential Pharmacological Treatmentsmentioning

confidence: 99%

Navigating the Unknown: A Comprehensive Review of Spaceflight-Associated Neuro-Ocular Syndrome

Mehare,

Chakole,

Wandile

2024

Cureus

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Spaceflight-associated neuro-ocular syndrome (SANS) is a complex and multifaceted condition that affects astronauts during and after their missions in space. This comprehensive review delves into the various aspects of SANS, providing a thorough understanding of its definition, historical context, clinical presentation, epidemiology, diagnostic techniques, preventive measures, and management strategies. Various ocular and neurological symptoms, including visual impairment, optic disc edema, choroidal folds, retinal changes, and increased intracranial pressure, characterize SANS. While microgravity is a primary driver of SANS, other factors like radiation exposure, genetic predisposition, and environmental conditions within spacecraft contribute to its development. The duration of space missions is a significant factor, with longer missions associated with a higher incidence of SANS. This review explores the diagnostic criteria and variability in SANS presentation, shedding light on early detection and management challenges. The epidemiology section provides insights into the occurrence frequency, affected astronauts' demographics, and differences between long-term and short-term missions. Diagnostic tools, including ophthalmological assessments and imaging techniques, are crucial in monitoring astronaut health during missions. Preventive measures are vital in mitigating the impact of SANS. Current strategies, ongoing research in prevention methods, lifestyle and behavioral factors, and the potential role of artificial gravity are discussed in detail. Additionally, the review delves into interventions, potential pharmacological treatments, rehabilitation, and long-term management considerations for astronauts with SANS. The conclusion underscores the importance of continued research in SANS, addressing ongoing challenges, and highlighting unanswered questions. With the expansion of human space exploration, understanding and managing SANS is imperative to ensure the health and well-being of astronauts during long-duration missions. This review is a valuable resource for researchers, healthcare professionals, and space agencies striving to enhance our knowledge and address the complexities of SANS.

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Section: Potential Pharmacological Treatmentsmentioning

confidence: 99%

Navigating the Unknown: A Comprehensive Review of Spaceflight-Associated Neuro-Ocular Syndrome

Mehare,

Chakole,

Wandile

2024

Cureus

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“…Stote, K.S. et al conducted a randomized, single-blind human intervention trial using 100% wild blueberry juice and observed that the short-term consumption of 240 mL of wild blueberry juice per day may promote cardioprotective effects in adults at risk of type 2 diabetes by improving the systolic blood pressure (possibly through nitric oxide production) [112,113]. The berries and stilbene in blueberries also exhibit preventive effects for several cancers [114].…”

Section: Health Value and Prospects Of Blueberriesmentioning

confidence: 99%

The Research Progress of Extraction, Purification and Analysis Methods of Phenolic Compounds from Blueberry: A Comprehensive Review

Bai

Zhou

et al. 2023

Molecules

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Blueberry is the source of a variety of bioactive substances, including phenolic compounds, such as anthocyanins, pterostilbene, phenolic acids, etc. Several studies have revealed that polyphenols in blueberry have important bioactivities in maintaining health, such as antioxidant and anti-tumor activities, immune regulation, the prevention of chronic diseases, etc. Therefore, these phenolic compounds in blueberries have been widely used in the field of healthcare, and the extraction, isolation, and purification of phenolic compounds are the prerequisites for their utilization. It is imperative to systematically review the research progress and prospects of phenolic compounds present in blueberries. Herein, the latest progress in the extraction, purification, and analysis of phenolic compounds from blueberries is reviewed, which can in turn provide a foundation for further research and usage of blueberries.

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“…Despite obvious limitations, preclinical and clinical studies strongly support the role of nutraceuticals in the management of sight-threatening retinopathies [ 25 , 88 , 89 ], as thoroughly reviewed in other recent publications [ 87 , 90 , 91 ]. Differently, in the present review, we aim to provide a pragmatic overview of the intersection between the use of pharmaceutical drugs and food supplements intended as nutraceuticals.…”

Section: Nutraceuticals: Which Place In the Management Of Neovascular...mentioning

confidence: 99%

Pharmacotherapy and Nutritional Supplements for Neovascular Eye Diseases

Rusciano

Bagnoli

2023

Medicina

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In this review, we aim to provide an overview of the recent findings about the treatment of neovascular retinal diseases. The use of conventional drugs and nutraceuticals endowed with antioxidant and anti-inflammatory properties that may support conventional therapies will be considered, with the final aim of achieving risk reduction (prevention) and outcome improvement (cooperation between treatments) of such sight-threatening proliferative retinopathies. For this purpose, we consider a medicinal product one that contains well-defined compound(s) with proven pharmacological and therapeutic effects, usually given for the treatment of full-blown diseases. Rarely are prescription drugs given for preventive purposes. A dietary supplement refers to a compound (often an extract or a mixture) used in the prevention or co-adjuvant treatment of a given pathology. However, it must be kept in mind that drug–supplement interactions may exist and might affect the efficacy of certain drug treatments. Moreover, the distinction between medicinal products and dietary supplements is not always straightforward. For instance, melatonin is formulated as a medicinal product for the treatment of sleep and behavioral problems; at low doses (usually below 1 mg), it is considered a nutraceutical, while at higher doses, it is sold as a psychotropic drug. Despite their lower status with respect to drugs, increasing evidence supports the notion of the beneficial effects of dietary supplements on proliferative retinopathies, a major cause of vision loss in the elderly. Therefore, we believe that, on a patient-by-patient basis, the administration of nutraceuticals, either alone or in association, could benefit many patients, delaying the progression of their disease and likely improving the efficacy of pharmaceutical drugs.

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Nutraceuticals: A Promising Therapeutic Approach in Ophthalmology

Cited by 17 publications

References 249 publications

Navigating the Unknown: A Comprehensive Review of Spaceflight-Associated Neuro-Ocular Syndrome

Navigating the Unknown: A Comprehensive Review of Spaceflight-Associated Neuro-Ocular Syndrome

The Research Progress of Extraction, Purification and Analysis Methods of Phenolic Compounds from Blueberry: A Comprehensive Review

Pharmacotherapy and Nutritional Supplements for Neovascular Eye Diseases

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