Nutraceuticals and Cancer

Sarkar, Fazlul H.

doi:10.1007/978-94-007-2630-7

Cited by 10 publications

(1 citation statement)

References 606 publications

(883 reference statements)

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“…the molecular structure of polyphenols, the physicochemical properties of molecules which, among other things, allows: (a) direct binding to the receptor proteins and inhibition of growth factors, tyrosine tyrosine kinases [41], (b) participation in cell signalling pathways, ROS-dependent pathways, including the antioxidant defence-related, inhibition of enzymes involved in the free radical generation [12,42,43] (c) scavenging of free radicals and binding (complexation) of transition metal ions (Cu 2+ , Fe 2+ ), (d) modulating the activity of epigenetic factors, e.g. activation of SIRT (sirtuin) by interacting with particular amino acid residues [44], regulation of genes involved in chromatin remodelling [45], (e) generation of reactive oxygen species (pro-oxidative activity), which causes cell cycle arrest, induction of apoptosis and DNA fragmentation [12].…”

Section: Plos Onementioning

confidence: 99%

Correlations between molecular structure and biological activity in "logical series" of dietary chromone derivatives

et al. 2020

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The research was conducted in the "logical series" of seven ligands: chromone, flavone, 3hydroxyflavone, 3,7-dihydroxyflavone, galangin, kaempferol and quercetin. Each subsequent ligand differs from the previous one, among others by an additional hydroxyl group. The studied chromone derivatives are plant secondary metabolites which play an important role in growth, reproduction, and resistance to pathogens. They are important food ingredients with valuable pro-health properties. The studies of the relationships between their molecular structure and biological activity facilitate searching for new chemical compounds with important biological properties not by trial and error, but concerning the impact of specific changes in their structure on the compound properties. Therefore several pectroscopic methods (FT-IR, FT-Raman, 1 H and 13 C NMR) were applied to study the molecular structure of the compounds in the series. Moreover the quantum-chemical calculations at B3LYP/6-311++G** were performed to obtained the theoretical NMR spectra, NBO atomic charge, global reactivity descriptors and thermodynamic parameters. The antioxidant activity of the compounds was tested in the DPPH and FRAP assays and the mechanism of antioxidant activity was discussed based on the results on theoretical calculations. The cytotoxicity of the ligands toward human epithelial colorectal adenocarcinoma Caco2 cells was estimated and correlated with the lipophilicity of the compounds. The principal component analyses (PCA) and hierarchical cluster analysis were used to study the dependency between the molecular structure of ligands and their biological activity. The experimental data were related to the theoretical ones. The found regular changes in physicochemical properties correlated well with the systematic changes in antioxidant and biological properties.

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Section: Plos Onementioning

confidence: 99%

Correlations between molecular structure and biological activity in "logical series" of dietary chromone derivatives

et al. 2020

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Epigenetic regulation of miRNA‐cancer stem cells nexus by nutraceuticals

Ahmad

Bao

et al. 2013

Molecular Nutrition Food Res

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Nutraceuticals, the bioactive food components represented by many naturally occurring dietary compounds, have been investigated for a few decades for their numerous beneficial effects, including their anticancer properties. The initial interest in the cancer-preventing/therapeutic ability of these agents was based on their ability to affect multiple signaling pathways that are deregulated in cancer cells. With a shift in the focus of cancer research to the emerging areas such as epigenetic regulation, microRNAs (miRNAs) and the cancer stem cells (CSCs), nutraceuticals initially appeared out of place. However, research investigations over the last several years have slowly but firmly presented evidence that supports a relevance of these agents in modern day research. While nutraceuticals are increasingly being realized to alter miRNA/CSCs expression and function, the molecular mechanism(s) are not very clearly understood. Epigenetic regulation is one mechanism by which these agents exert their anticancer effects. In this focused mini review, we summarize our current understanding of epigenetic regulation of miRNAs and CSCs by nutraceuticals. We discuss both direct and indirect evidences that support such an activity of these compounds.

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Structure–activity relationships of anthocyanidin glycosylation

et al. 2014

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This paper summarizes the main achievements about the structure-activity relationships of anthocyanidin glycosylation. Anthocyanidin glycosylation is the essential step of anthocyanin biosynthesis and also the prerequisite of the further modifications of anthocyanins, which is jointly characterized by the glycosylation site, the type and number of the glycosyl as well as the glycosidic bond type. It generally enhances the stability, results in the hypsochromic effect and blueing, decreases the bioavailability and anticancer activity, and decreases, increases, or does not change the antioxidant activity of the anthocyanidins or anthocyanins, which is synergetically determined by the glycosylation site and the type and number of the glycosyl. Thereinto, in nature, the blue hues caused by the glycosylation may also be reinforced by the formation of the anthocyanic vacuolar inclusions. This review could provide a reference for the research of the structure-optimizing and function-exploiting of anthocyanins.

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Nutraceuticals and Cancer

Cited by 10 publications

References 606 publications

Correlations between molecular structure and biological activity in "logical series" of dietary chromone derivatives

Correlations between molecular structure and biological activity in "logical series" of dietary chromone derivatives

Epigenetic regulation of miRNA‐cancer stem cells nexus by nutraceuticals

Structure–activity relationships of anthocyanidin glycosylation

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