Nutraceuticals and Enteric Glial Cells

Gómez, Laura López; Szymaszkiewicz, Agata; Zielińska, Marta; Abalo, Raquel

doi:10.3390/molecules26123762

Cited by 11 publications

(8 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although available data is scarce, some studies suggest these compounds might have antioxidant, antiinflammatory, or modulatory effects on enteric glial cells. For example, compounds like palmitoylethanolamide, cannabidiol and berberine can reduce gut inflammation and nociception in both IBD models and patients (López-Gómez et al, 2021). For the first two, these effects were described to occur through the activation of PPARs in enteric glial cells (Filippis et al, 2011;Sarnelli et al, 2018).…”

Section: Could Enteric Glial Cells Be a Therapeutic Target For Parkin...mentioning

confidence: 99%

Enteric glia as a player of gut-brain interactions during Parkinson’s disease

Thomasi,

Valdetaro,

Ricciardi

et al. 2023

Front. Neurosci.

View full text Add to dashboard Cite

The enteric glia has been shown as a potential component of neuroimmune interactions that signal in the gut-brain axis during Parkinson’s disease (PD). Enteric glia are a peripheral glial type found in the enteric nervous system (ENS) that, associated with enteric neurons, command various gastrointestinal (GI) functions. They are a unique cell type, with distinct phenotypes and distribution in the gut layers, which establish relevant neuroimmune modulation and regulate neuronal function. Comprehension of enteric glial roles during prodromal and symptomatic phases of PD should be a priority in neurogastroenterology research, as the reactive enteric glial profile, gastrointestinal dysfunction, and colonic inflammation have been verified during the prodromal phase of PD—a moment that may be interesting for interventions. In this review, we explore the mechanisms that should govern enteric glial signaling through the gut-brain axis to understand pathological events and verify the possible windows and pathways for therapeutic intervention. Enteric glia directly modulate several functional aspects of the intestine, such as motility, visceral sensory signaling, and immune polarization, key GI processes found deregulated in patients with PD. The search for glial biomarkers, the investigation of temporal–spatial events involving glial reactivity/signaling, and the proposal of enteric glia-based therapies are clearly demanded for innovative and intestine-related management of PD.

show abstract

Section: Could Enteric Glial Cells Be a Therapeutic Target For Parkin...mentioning

confidence: 99%

Enteric glia as a player of gut-brain interactions during Parkinson’s disease

Thomasi,

Valdetaro,

Ricciardi

et al. 2023

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Much recent interest has been focused on the modulatory properties of EGCs for the treatment of different GI diseases, especially those characterised by chronic inflammation and altered neuroplasticity (e.g., disorders of GI hypersensitivity or motility). Most of these novel treatment strategies focus on preventing reactive gliosis 76 (reviewed in 96 ).…”

Section: Enteric Glial Cellsmentioning

confidence: 99%

Recent advances in understanding the roles of the enteric nervous system

Chanpong¹,

Borrelli²,

Thapar³

2022

Fac Rev

View full text Add to dashboard Cite

The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal (GI) tract, is a vast, mesh-like network of neurons and glia embedded within the bowel wall. Through its complex circuitry and neuronal diversity, the ENS is capable of functioning autonomously but is modulated by inputs from the central nervous system (CNS). The communication between the ENS and CNS is bidirectional and, together with crosstalk of these systems with microbiota housed within the GI tract, underpins the so-called microbiota-gut-brain axis. The ENS functions as a master regulator and coordinates many of the essential functions of the body, including GI motility, sensation and secretion. It is also capable of interacting with other cells, including intestinal epithelial, neuroendocrine and immune cells, to regulate their development as well as structural and functional integrity. Disruption of these ENS interactions, especially during early life, is likely to contribute to the aetiopathogenesis of disorders of the GI tract as well as elsewhere in the body, including neurodegenerative diseases. In this article, we highlight recent advances in our understanding of the roles of the ENS, especially in its complex and reciprocal interactions that influence GI motility, sensation, intestinal epithelial integrity, immunity and neuroendocrine function, particularly focusing on the influence of the ENS in early life and early life programming.

show abstract

“…In particular, several proteins are often used to identify EGCs, i.e., calcium-binding protein S100 [ 9 , 32 ], glial fibrillary acidic protein (GFAP) [ 9 , 33 ] and the transcription factors: SOX-8, SOX-9, SOX-10 [ 34 ] ( Figure 1 ). Interestingly, Hanani et al [ 35 ] and others [ 36 ], showed that EGCs are interconnected and electrically coupled by gap junctions and form an extensive functional glial network [ 37 ].…”

Section: The Enteric Nervous Systemmentioning

confidence: 99%

The Enteric Glia and Its Modulation by the Endocannabinoid System, a New Target for Cannabinoid-Based Nutraceuticals?

et al. 2022

Self Cite

View full text Add to dashboard Cite

The enteric nervous system (ENS) is a part of the autonomic nervous system that intrinsically innervates the gastrointestinal (GI) tract. Whereas enteric neurons have been deeply studied, the enteric glial cells (EGCs) have received less attention. However, these are immune-competent cells that contribute to the maintenance of the GI tract homeostasis through supporting epithelial integrity, providing neuroprotection, and influencing the GI motor function and sensation. The endogenous cannabinoid system (ECS) includes endogenous classical cannabinoids (anandamide, 2-arachidonoylglycerol), cannabinoid-like ligands (oleoylethanolamide (OEA) and palmitoylethanolamide (PEA)), enzymes involved in their metabolism (FAAH, MAGL, COX-2) and classical (CB1 and CB2) and non-classical (TRPV1, GPR55, PPAR) receptors. The ECS participates in many processes crucial for the proper functioning of the GI tract, in which the EGCs are involved. Thus, the modulation of the EGCs through the ECS might be beneficial to treat some dysfunctions of the GI tract. This review explores the role of EGCs and ECS on the GI tract functions and dysfunctions, and the current knowledge about how EGCs may be modulated by the ECS components, as possible new targets for cannabinoids and cannabinoid-like molecules, particularly those with potential nutraceutical use.

show abstract

Nutraceuticals and Enteric Glial Cells

Cited by 11 publications

References 119 publications

Enteric glia as a player of gut-brain interactions during Parkinson’s disease

Enteric glia as a player of gut-brain interactions during Parkinson’s disease

Recent advances in understanding the roles of the enteric nervous system

The Enteric Glia and Its Modulation by the Endocannabinoid System, a New Target for Cannabinoid-Based Nutraceuticals?

Contact Info

Product

Resources

About