Nutraceuticals and migraine: further strategy for the treatment of specific conditions

Quintana, Simone; Russo, Marco; Torelli, Paola

doi:10.1007/s10072-022-06250-1

Cited by 6 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Migraine is considered a threshold disease induced by a brain-related trigger, and some dietary nutrients are considered as such triggers (reviewed in [ 8 , 12 ]). However, some other nutrients, including nutraceuticals, may play a role in migraine prevention and prophylaxis [ 13 , 14 , 15 , 16 ]. Although many papers suggest an important role of diet modifications in migraine prevention and treatment, these suggestions lack a strong evidence base (reviewed in [ 17 ]).…”

Section: Migraine As a Diet-sensitive Diseasementioning

confidence: 99%

See 1 more Smart Citation

Nutrition and Calcitonin Gene Related Peptide (CGRP) in Migraine

et al. 2023

View full text Add to dashboard Cite

Targeting calcitonin gene-related peptide (CGRP) and its receptor by antibodies and antagonists was a breakthrough in migraine prevention and treatment. However, not all migraine patients respond to CGRP-based therapy and a fraction of those who respond complain of aliments mainly in the gastrointestinal tract. In addition, CGRP and migraine are associated with obesity and metabolic diseases, including diabetes. Therefore, CGRP may play an important role in the functioning of the gut-brain-microflora axis. CGRP secretion may be modulated by dietary compounds associated with the disruption of calcium signaling and upregulation of mitogen-activated kinase phosphatases 1 and 3. CGRP may display anorexigenic properties through induction of anorexigenic neuropeptides, such as cholecystokinin and/or inhibit orexigenic neuropeptides, such as neuropeptide Y and melanin-concentrating hormone CH, resulting in the suppression of food intake, functionally coupled to the activation of the hypothalamic 3′,5′-cyclic adenosine monophosphate. The anorexigenic action of CGRP observed in animal studies may reflect its general potential to control appetite/satiety or general food intake. Therefore, dietary nutrients may modulate CGRP, and CGRP may modulate their intake. Therefore, anti-CGRP therapy should consider this mutual dependence to increase the efficacy of the therapy and reduce its unwanted side effects. This narrative review presents information on molecular aspects of the interaction between dietary nutrients and CGRP and their reported and prospective use to improve anti-CGRP therapy in migraine.

show abstract

Section: Migraine As a Diet-sensitive Diseasementioning

confidence: 99%

“…Nutraceuticals, food or dietary supplements exerting beneficial health effects were studied in migraine prevention and therapy (reviewed in [ 16 ]). They are magnesium, coenzyme Q10, feverfew, riboflavin, phycocyanin, vitamin D and others.…”

Section: Migraine As a Diet-sensitive Diseasementioning

confidence: 99%

Nutrition and Calcitonin Gene Related Peptide (CGRP) in Migraine

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Many food supplements and nutraceuticals have been studied in relation to nervous disease treatment and prevention. Magnesium, coenzyme Q10, feverfew, riboflavin, and phycocyanins have shown modest efficacy but a very good safety and tolerability profile in migraine treatment [38]. Diets with a low nutrient density are linked to a higher risk of cognitive decline [39].…”

Section: Nutrient Interactionsmentioning

confidence: 99%

Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders

Badaeva

Danilov

Clayton³

et al. 2023

Nutrients

View full text Add to dashboard Cite

The term neuronutrition has been proposed as part of nutritional neuroscience, studying the effects of various dietary components on behavior and cognition. Other researchers underline that neuronutrition includes the use of various nutrients and diets to prevent and treat neurological disorders. The aim of this narrative review was to explore the current understanding of the term neuronutrition as the key concept for brain health, its potential molecular targets, and perspectives of its nutritional approach to the prevention and treatment of Alzheimer’s and Parkinson’s diseases, multiple sclerosis, anxiety, depressive disorders, migraine, and chronic pain. Neuronutrition can be defined as a part of neuroscience that studies the influence of various aspects of nutrition (nutrients, diet, eating behavior, food environment, etc.) on the development of nervous disorders and includes nutrition, clinical dietetics, and neurology. There is evidence that the neuronutritional approach can influence neuroepigenetic modifications, immunological regulation, metabolic control, and behavioral patterns. The main molecular targets in neuronutrition include neuroinflammation, oxidative/nitrosative stress and mitochondrial dysfunction, gut–brain axis disturbance, and neurotransmitter imbalance. To effectively apply neuronutrition for maintaining brain health, a personalized approach is needed, which includes the adaptation of the scientific findings to the genetic, biochemical, psycho-physiological, and environmental features of each individual.

show abstract

“…For instance, it has been proposed that dietary nutrients may alter the level and function of CGRP, and CGRP may influence food intake [80]. Therapeutic nutritional recommendations are expected to be adjusted to patient needs, for example, for children, adolescents [81], pregnant or nursing women, and geriatrics with migraine [82]. Behavior change strategies considering other lifestyle factors in addition to the diet (e.g., sleep, stress, and exercise) seem essential to be implemented in future plans [83 ▪ ].…”

Section: Future Developmentsmentioning

confidence: 99%

Diet and migraine: what is proven?

Gazerani

2023

Current Opinion in Neurology

View full text Add to dashboard Cite

Purpose of review The purpose of this review is to present the latest research findings about diet and migraine, what can be used in the clinic now, and what needs further investigation. Recent findings Recent findings highlight that dietary triggers exist for migraine, for example, coffee and alcohol, according to a new systematic review. Elimination diets must be personalized to delineate a balanced diet with acceptable quality and pattern. A piece of average-quality evidence shows that the ketogenic diet (KD) and the Dietary Approaches to Stop Hypertension (DASH) are effective in reducing the frequency, duration, and severity of migraine headaches in adult patients. The gut microbiome is altered in patients with migraine, and further research will identify the benefits of pre and probiotic use for migraine. Advanced digital technology in continuous monitoring can provide educational content based on patients’ needs, help patients adhere to dietary plans, and strengthen personalized care. The complex interaction of lifestyle factors, the influence of age and sex, and patients’ needs in various life phases are essential in formulating dietary plans. Summary The diet-migraine interaction is a dynamic bidirectional phenomenon that requires careful monitoring, review, and justification of dietary choices to yield the optimal outcome while minimizing potential risks.

show abstract

Nutraceuticals and migraine: further strategy for the treatment of specific conditions

Cited by 6 publications

References 10 publications

Nutrition and Calcitonin Gene Related Peptide (CGRP) in Migraine

Nutrition and Calcitonin Gene Related Peptide (CGRP) in Migraine

Perspectives on Neuronutrition in Prevention and Treatment of Neurological Disorders

Diet and migraine: what is proven?

Contact Info

Product

Resources

About