Nutraceuticals and Nutrition Supplements: Challenges and Opportunities

Siddiqui, Rafat A.; Moghadasian, Mohammed H.

doi:10.3390/nu12061593

Cited by 34 publications

(20 citation statements)

References 29 publications

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“…More recently, nutraceuticals have become the focus of farm animal production. These nutraceuticals are rich in plant-derived immune stimulants such as phytochemicals, vitamins, and minerals ( 59 ). Several pre-, pro-, and synbiotic-based functional medicines have already been explored thoroughly and have demonstrated the ability to rebalance dysbiotic intestinal flora and preserve animal health ( 60 ).…”

Section: Introductionmentioning

confidence: 99%

Nutraceuticals Induced Changes in the Broiler Gastrointestinal Tract Microbiota

et al. 2021

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Effects of nutraceuticals on the intestinal microbiota are receiving increased attention; however, there are few studies investigating their effects on broiler meat production. The aim of this study was to implement feeding strategies and carry out a comprehensive trial examining the interplay between natural biologically active compounds such as carotenoids, anthocyanins, fermentable oligosaccharides, and synbiotics and the gastrointestinal tract microbiota. Our feeding program was applied to an intensive production system with a flock of 1,080 Ross 308 broilers. Aging induced significant changes through the feeding experiment. Nutraceuticals were shown to modulate broiler intestinal diversity and differentially enriched Lactobacillus, Enterococcus, Campylobacter, and Streptococcus in the core microbiome during the different stages of broiler rearing. Additionally, they did not remarkably affect animal growth performance; nevertheless, a positive correlation was found between body weight and Corynebacteriales and Pseudomonadales. Furthermore, a diet high in carotenoid, fermentable oligosaccharide, and anthocyanin contents affected the number of beneficial genera such as Faecalibacterium, Lactobacillus, Blautia, and Ruminococcus. With this comprehensive trial, we revealed that nutraceuticals induced modulations in broiler gastrointestinal tract microbiota. We believe that plant-derived immunostimulants, recycled from plant food waste products, can supplement antibiotic-free broiler meat production. IMPORTANCE In this trial, nutraceuticals were manufactured from waste products of food industry processing of Hungarian red sweet pepper and sour cherry and incorporated into the diet of poultry to investigate their effects on broilers’ growth and the broiler gastrointestinal tract microbiota. To avoid the generation of food waste products, we believe that this approach can be developed into a sustainable, green approach that can be implemented in commercial antibiotic-free poultry to provide safe and high-quality meat.

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Section: Introductionmentioning

confidence: 99%

Nutraceuticals Induced Changes in the Broiler Gastrointestinal Tract Microbiota

et al. 2021

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“…In general, the conventional techniques that are naturally available and used by industries do not always allow the production of inexpensive quality extracts and thus low-cost strategies to prevent or treat OA disease. The problem of cheap but poor-quality nutraceutical extracts is a serious, underestimated, and potentially dangerous problem for people’s health, not only because of the absence of specific active ingredients or the low quality of un-titrated extracts, but above all due to the presence of contaminants [ 168 ]. An important challenge for the future is to develop a food-compatible method for the extraction of specific phytochemicals and thus produce qualitatively effective and safe nutraceutical extracts with anti-OA properties.…”

Section: Discussionmentioning

confidence: 99%

Nutraceutical Approach to Chronic Osteoarthritis: From Molecular Research to Clinical Evidence

Colletti

Cicero

2021

IJMS

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Osteoarthritis (OA) is a degenerative inflammatory condition of the joint cartilage that currently affects approximately 58 million adults in the world. It is characterized by pain, stiffness, and a reduced range of motion with regard to the arthritic joints. These symptoms can cause in the long term a greater risk of overweight/obesity, diabetes mellitus, and falls and fractures. Although the current guidelines for the treatment of OA suggest, as the gold standard for this condition, pharmacological treatment characterized by non-steroidal anti-inflammatory drugs (NSAID), opioids, and cyclooxygenase (COX)-2-specific drugs, a great interest has been applied to nutraceutical supplements, which include a heterogeneous class of molecules with great potential to reduce inflammation, oxidative stress, pain, and joint stiffness and improve cartilage formation. The purpose of this review is to describe the potential application of nutraceuticals in OA, highlighting its molecular mechanisms of actions and data of efficacy and safety (when available).

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“…Nutraceuticals derived from plant phenolic substances are credited for various beneficial effects towards the preventive approach against common diseases and disorders such as diabetes, cancer, osteoporosis, obesity, and cardiovascular complications [5,6,15,16]. Quercetin is a popular and widely researched phytochemical in this sense, with reported bioactivities [17,18].…”

Section: Discussionmentioning

confidence: 99%

Effect of Quercetin 3-O-β-D-Galactopyranoside on the Adipogenic and Osteoblastogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stromal Cells

Karadeniz

Seo

et al. 2020

IJMS

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Natural products, especially phenols, are promising therapeutic agents with beneficial effects against aging-related complications such as osteoporosis. This study aimed to investigate the effect of quercetin 3-O-β-D-galactopyranoside (Q3G), a glycoside of a common bioactive phytochemical quercetin, on osteogenic and adipogenic differentiation of human bone marrow-derived mesenchymal stromal cells (hBM-MSCs). hBM-MSCs were induced to differentiate into osteoblasts and adipocytes in the presence or absence of Q3G and the differentiation markers were analyzed to observe the effect. Q3G treatment stimulated the osteoblastogenesis markers: cell proliferation, alkaline phosphatase (ALP) activity and extracellular mineralization. In addition, it upregulated the expression of RUNX2 and osteocalcin protein as osteoblastogenesis regulating transcription factors. Moreover, Q3G treatment increased the activation of osteoblastogenesis-related Wnt and bone morphogenetic protein (BMP) signaling displayed as elevated levels of phosphorylated β-catenin and Smad1/5 in nuclear fractions of osteo-induced hBM-MSCs. The presence of quercetin in adipo-induced hBM-MSC culture inhibited the adipogenic differentiation depicted as suppressed lipid accumulation and expression of adipogenesis markers such as PPARγ, SREBP1c and C/EBPα. In conclusion, Q3G supplementation stimulated osteoblast differentiation and inhibited adipocyte differentiation in hBM-MSCs via Wnt/BMP and PPARγ pathways, respectively. This study provided useful information of the therapeutic potential of Q3G against osteoporosis mediated via regulation of MSC differentiation.

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Nutraceuticals and Nutrition Supplements: Challenges and Opportunities

Abstract: The term “nutraceuticals” is derived from “nutrition” and “pharmaceuticals” and is used fornutrition products that are also used as medicine [1] [...]

Cited by 34 publications

References 29 publications

Nutraceuticals Induced Changes in the Broiler Gastrointestinal Tract Microbiota

Nutraceuticals Induced Changes in the Broiler Gastrointestinal Tract Microbiota

Nutraceutical Approach to Chronic Osteoarthritis: From Molecular Research to Clinical Evidence

Effect of Quercetin 3-O-β-D-Galactopyranoside on the Adipogenic and Osteoblastogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stromal Cells

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