Nutraceuticals and Pharmaceuticals from Marine Fish and Invertebrates

Šimat, Vida

doi:10.3390/md19070401

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…In contrast to the traditionally low value attributed to fishery by-products, several studies have revealed that fish waste biomass holds immense potential as a rich source of high-value biomolecules such as functional components, nutraceuticals, and pharmaceuticals. [5][6][7][8][9][10][11][12] In this context, implementing a solid waste management strategy that involves recycling these byproducts into marketable products could be an effective solution. 13 Viscera, a significant by-product of the fisheries sector, possess immense potentiality as a valuable and cost-effective natural source of digestive proteases that display remarkable efficacy across a broad spectrum of temperature and pH.…”

Section: Introductionmentioning

confidence: 99%

Purification of Trypsin from Sardine (Sardina pilchardus) Viscera and Its Application in Preparation of Antioxidative Fish Protein Hydrolysates

2024

TJNPR

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Among the alkaline proteases in fish viscera, trypsin is one the key members, belonging to the serine-protease family (EC. 3.4.21). 20 Recently, special focus has been on the isolation of trypsins from fish viscera as a value-added product with versatile applications in several sectors. 21,22 Trypsins are utilized as essential components in detergents. 18,23,24 Additionally, they play a crucial role in extracting carotenoproteins from shrimp waste, 25,26,27 contributing to the production of protein hydrolysates that serve as valuable source of biopeptides. 28,29,30 Moreover, promoting the sustainable use of fish byproducts for human consumption stands as a top priority. Nowadays, the formation of fish protein hydrolysates (FPH) stands as one of the promising industrial applications of fish by-products. 31,32,33 The outstanding functional (emulsifier, foaming compounds) bioactive activities (antioxidant, antihypertensive, antibacterial), and nutritional properties of FPH broaden its range of applications. In fact, multiple reviews have uncovered the diverse bioactivities of hydrolysates and peptides derived from marine by-products, as well as their current and potential applications. 6,[34][35][36][37][38][39][40] The most efficient methods for obtaining protein hydrolysates from fish waste are considered to be bioconversion through enzymatic hydrolysis and fermentation. In fact, natural antioxidants are favored over chemically synthesized ones due to their GRAS statue (Generally Recognized As Safe). 41,42 Proteases from animals, plants, bacteria, and fungi have been applied in addition to the bacterial commercial protease Alcalase®. 28,[43][44][45][46] The primary species captured along the Moroccan coast is the sardine (S. pilchardus), with the majority of this harvest being employed in the production of canned sardines. The processing of raw materials results in the production of by-products such as heads, viscera, and muscle.

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Section: Introductionmentioning

confidence: 99%

Purification of Trypsin from Sardine (Sardina pilchardus) Viscera and Its Application in Preparation of Antioxidative Fish Protein Hydrolysates

2024

TJNPR

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“…The massive diversification of organisms in the marine ecosystem serves as a reservoir of a wide range of natural compounds (1,2). New marine molecules and their biological potential are discovered every year, allowing these compounds to be used in functional foods and the development of new nutraceuticals and therapeutic drugs (3,4). In Asian countries, particularly China, Korea, and Japan, marine algae have long been consumed as food, whereas in Western countries, algae are mostly used as a source of food additives (5), natural pigment (6), and minerals (7).…”

Section: Introductionmentioning

confidence: 99%

Potent Bioactive Compounds From Seaweed Waste to Combat Cancer Through Bioinformatics Investigation

Bharadwaj

Ahmad

Pati³

et al. 2022

Front. Nutr.

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The seaweed industries generate considerable amounts of waste that must be appropriately managed. This biomass from marine waste is a rich source of high-value bioactive compounds. Thus, this waste can be adequately utilized by recovering the compounds for therapeutic purposes. Histone deacetylases (HDACs) are key epigenetic regulators established as one of the most promising targets for cancer chemotherapy. In the present study, our objective is to find the HDAC 2 inhibitor. We performed top-down in silico methodologies to identify potential HDAC 2 inhibitors by screening compounds from edible seaweed waste. One hundred ninety-three (n = 193) compounds from edible seaweeds were initially screened and filtered with drug-likeness properties using SwissADME. After that, the filtered compounds were followed to further evaluate their binding potential with HDAC 2 protein by using Glide high throughput virtual screening (HTVS), standard precision (SP), extra precision (XP), and quantum polarized ligand docking (QPLD). One compound with higher negative binding energy was selected, and to validate the binding mode and stability of the complex, molecular dynamics (MD) simulations using Desmond were performed. The complex-binding free energy calculation was performed using molecular mechanics-generalized born surface area (MM-GBSA) calculation. Post-MD simulation analyses such as PCA, DCCM, and free energy landscape were also evaluated. The quantum mechanical and electronic properties of the potential bioactive compounds were assessed using the density functional theory (DFT) study. These findings support the use of marine resources like edible seaweed waste for cancer drug development by using its bioactive compounds. The obtained results encourage further in vitro and in vivo research. Our in silico findings show that the compound has a high binding affinity for the catalytic site of the HDAC 2 protein and has drug-likeness properties, and can be utilized in drug development against cancer.

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Extraction of Bioactive and Nutraceuticals from Marine Sources and Their Application

Rathod,

Reddy,

Čagalj

et al. 2024

Methods and Protocols in Food Science

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Nutraceuticals and Pharmaceuticals from Marine Fish and Invertebrates

Abstract: The word nutraceutical is coined from two words, “nutrition” and “pharmaceutical”, describing natural sources of molecules or substances that have physiological benefit, and the ability to protect human health and well-being and prevent chronic diseases [...]

Cited by 6 publications

References 11 publications

Purification of Trypsin from Sardine (Sardina pilchardus) Viscera and Its Application in Preparation of Antioxidative Fish Protein Hydrolysates

Purification of Trypsin from Sardine (Sardina pilchardus) Viscera and Its Application in Preparation of Antioxidative Fish Protein Hydrolysates

Potent Bioactive Compounds From Seaweed Waste to Combat Cancer Through Bioinformatics Investigation

Extraction of Bioactive and Nutraceuticals from Marine Sources and Their Application

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