Nutraceuticals in Respiratory Disorders

Gulati, Kavita; Rai, Nishant; Chaudhary, Sulekha; Ray, Arunabha

doi:10.1016/b978-0-12-802147-7.00006-1

Cited by 18 publications

(8 citation statements)

References 129 publications

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“…Sepsis TNF-𝛼, IFN-𝛾, TGF-𝛽, MIF, IL-1, IL-6, IL-4, IL-10, IL-12 [ 224] Aging IL-6, IL-8, IL-10, IL-13, TNF-𝛼, IFN-𝛾 [ 225] significance on immune cell differentiation, inflammation, angiogenesis, tumorigenesis, neurobiology, viral pathogenesis, atherosclerosis, cancer, and aging. [72] Table 2 illustrates different typical diseases related to the interactions of various cytokines. This supports the model that cytokines act as biomarkers for a variety of autoimmune and inflammatory diseases.…”

Section: Anti-inflammatory Cytokinesmentioning

confidence: 99%

Cytokines: From Clinical Significance to Quantification

et al. 2021

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Cytokines are critical mediators that oversee and regulate immune and inflammatory responses via complex networks and serve as biomarkers for many diseases. Quantification of cytokines has significant value in both clinical medicine and biology as the levels provide insights into physiological and pathological processes and can be used to aid diagnosis and treatment. Cytokines and their clinical significance are introduced from the perspective of their pro‐ and anti‐inflammatory effects. Factors affecting cytokines quantification in biological fluids, native levels in different body fluids, sample processing and storage conditions, sensitivity to freeze‐thaw, and soluble cytokine receptors are discussed. In addition, recent advances in in vitro and in vivo assays, biosensors based on different signal outputs and intracellular to extracellular protein expression are summarized. Various quantification platforms for high‐sensitivity and reliable measurement of cytokines in different scenarios are discussed, and commercially available cytokine assays are compared. A discussion of challenges in the development and advancement of technologies for cytokine quantification that aim to achieve real‐time multiplex cytokine analysis for point‐of‐care situations applicable for both biomedical research and clinical practice are discussed.

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Section: Anti-inflammatory Cytokinesmentioning

confidence: 99%

Cytokines: From Clinical Significance to Quantification

et al. 2021

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“…Bromhexine or bromhexine hydrochloride (N-cyclo-N-methyl-(2-amino-3,5-dibromo-benzyl) amine hydrochloride) is derived from Vasicin, a plant-derived ingredient and alkaloid that was developed from the Indian lung herb, Adhatoda vasica, and is a brominated aniline and benzylamine derivative [62]. Bromhexine hydrochloride acts as a mucolytic (breaks down mucus and helps clear chest congestion) and is approved in many countries as an OTC drug.…”

Section: Is There An Ideal Drug For a Pandemic Like Covid-19?mentioning

confidence: 99%

Potential new treatment strategies for COVID-19: is there a role for bromhexine as add-on therapy?

Depfenhart

Villiers²,

Lemperle

et al. 2020

Intern Emerg Med

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Of huge importance now is to provide a fast, cost-effective, safe, and immediately available pharmaceutical solution to curb the rapid global spread of SARS-CoV-2. Recent publications on SARS-CoV-2 have brought attention to the possible benefit of chloroquine in the treatment of patients infected by SARS-CoV-2. Whether chloroquine can treat SARS-CoV-2 alone and also work as a prophylactic is doubtful. An effective prophylactic medication to prevent viral entry has to contain, at least, either a protease inhibitor or a competitive virus ACE2-binding inhibitor. Using bromhexine at a dosage that selectively inhibits TMPRSS2 and, in so doing, inhibits TMPRSS2-specific viral entry is likely to be effective against SARS-CoV-2. We propose the use of bromhexine as a prophylactic and treatment. We encourage the scientific community to assess bromhexine clinically as a prophylactic and curative treatment. If proven to be effective, this would allow a rapid, accessible, and cost-effective application worldwide.

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“…They also exert different activities, such as antifungal, antioxidant, antiaggregant and antidiabetic effects 17,19,20 . Boswellia serrata from Burseraceae family is a medium‐sized tree found in South Asia, Northern Africa and Middle East 21 . The gum resin of B serrata contains boswellic acid which is known to possess many biological properties, such as anti‐inflammatory, antimicrobial, gastrointestinal and hormonal properties 22 .…”

Section: Introductionmentioning

confidence: 99%

Identification of the chemical composition of six essential oils with mass spectroscopy and evaluation of their antibacterial and antioxidant potential

Irahal

Lahlou

Hmimid

et al. 2021

Flavour & Fragrance J

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This study determined the chemical composition of Cinnamomum verum J.Presl, Cistus ladaniferus L., Laurus nobilis L., Senecio anteuphorbuim, Boswellia serrata Roxb. ex Colebr. and Schinus molle L. essential oils (EOs) by gas chromatography‐mass spectrometry. Moreover, the six EOs were screened in order to reveal their antibacterial and antioxidant activities. They were initially tested against six pathogenic bacteria: Staphylococcus aureus (MRSA: methicillin‐resistant Staphylococcus aureus), Escherichia coli (ESBL: extended‐spectrum β‐lactamases), Enterococcus faecalis (VRE: vancomycin‐resistant enterococcus), Klebsiella pneumoniae (CRK: carbapenem‐resistant klebsiella), clinical isolate Staphylococcus aureus and Escherichia coli ATCC 25922. Then, the antioxidant effect was assessed by β‐carotene‐linoleic acid. Cinnamomum verum J.Presl, Cistus ladaniferus L. and Laurus nobilis L. exhibited the greatest antibacterial activity except Boswellia serrata Roxb. ex Colebr. oil. But this last one showed the highest antioxidant activity (85.75%) comparable to that of BHT (98.25%). The principal component analysis between the antibacterial activity and the twenty major components of six EOs revealed that α‐pinene, β‐pinene, 4‐carene, α‐phellandrene, 1,8‐cineole, linalool, 1,3,8‐p‐menthatriene, α‐terpineol, cinnamyl alcohol and cinnamaldehyde are responsible for their antibacterial activity against multi‐resistant strains. From this study, the results obtained show that the EOs may constitute an alternative to the emergence of multidrug‐resistant bacteria.

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Nutraceuticals in Respiratory Disorders

Cited by 18 publications

References 129 publications

Cytokines: From Clinical Significance to Quantification

Cytokines: From Clinical Significance to Quantification

Potential new treatment strategies for COVID-19: is there a role for bromhexine as add-on therapy?

Identification of the chemical composition of six essential oils with mass spectroscopy and evaluation of their antibacterial and antioxidant potential

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