Nutraceuticals: Reviewing their Role in Chronic Disease Prevention and Management

Bergamin, Amanda; Mantzioris, Evangeline; Cross, Giordana; Deo, Permal; Garg, Sanjay; Hill, Alan R.

doi:10.1007/s40290-019-00289-w

Cited by 33 publications

(30 citation statements)

References 152 publications

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“…There is also a growing interest in the role of caloric restriction diet and nutraceutical compounds on the regulation of expression of adipokines, myokines, and cardiokines [11].…”

Section: Introductionmentioning

confidence: 99%

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Senesi

Luzi

Terruzzi

2020

IJMS

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: It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs and secrete in normal and in pathological conditions several molecules, called, respectively, adipokines, myokines, and cardiokines. These secretory proteins constitute a closed network that plays a crucial role in obesity and above all in cardiac diseases associated with obesity. In particular, the interaction between adipokines, myokines, and cardiokines is mainly involved in inflammatory and oxidative damage characterized obesity condition. Identifying new therapeutic agents or treatment having a positive action on the expression of these molecules could have a key positive effect on the management of obesity and its cardiac complications. Results from recent studies indicate that several nutritional interventions, including nutraceutical supplements, could represent new therapeutic agents on the adipo-myo-cardiokines network. This review focuses the biological action on the main adipokines, myokines and cardiokines involved in obesity and cardiovascular diseases and describe the principal nutraceutical approaches able to regulate leptin, adiponectin, apelin, irisin, natriuretic peptides, and follistatin-like 1 expression.

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“…There is also a growing interest in the role of caloric restriction diet and nutraceutical compounds on the regulation of expression of adipokines, myokines, and cardiokines [11].…”

Section: Introductionmentioning

confidence: 99%

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Senesi

Luzi

Terruzzi

2020

IJMS

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“…The first definition of "nutraceuticals" was formed in 1989 by Dr Stephen L. De Felice, a founder and chairman of the Foundation for Innovations in Medicine [20,21]. According to the definition, nutraceuticals are any natural non-toxic food products, extracts, or food derivatives containing bioactive chemical substances, such as herbs, vitamins, amino acids, minerals, and enzymes with scientifically proven beneficial properties in the field of disease prevention and treatment [22,23]. These substances have been suggested to provide protection against chronic diseases including renal disease diabetes, neurological and gastrointestinal disorders, and cancers [24].…”

Section: Nutraceuticalsmentioning

confidence: 99%

Are Nutraceuticals Beneficial in Chronic Kidney Disease?

et al. 2021

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Chronic kidney disease (CKD) is a worldwide health problem in which prevalence is constantly rising. The pathophysiology of CKD is complicated and has not been fully resolved. However, elevated oxidative stress is considered to play a vital role in the development of this disease. CKD is also thought to be an inflammatory disorder in which uremic toxins participate in the development of the inflammatory milieu. A healthy, balanced diet supports the maintenance of a good health status as it helps to reduce the risk of the development of chronic diseases, including chronic kidney disease, diabetes mellitus, and hypertension. Numerous studies have demonstrated that functional molecules and nutrients, including fatty acids and fiber as well as nutraceuticals such as curcumin, steviol glycosides, and resveratrol not only exert beneficial effects on pro-inflammatory and anti-inflammatory pathways but also on gut mucosa. Nutraceuticals have attracted great interest recently due to their potential favorable physiological effects on the human body and their safety. This review presents some nutraceuticals in which consumption could exert a beneficial impact on the development and progression of renal disease as well cardiovascular disease.

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“…[47][48][49][50] Validation processes are multiple, control processes important for quality production, and clinical trials increasing for safe and efficacy, but it must be avoided the "allopathization of phytotherapy". 51 Trophotherapy and nutraceuticals are the preventive and curative method through healthy food and diet, looking for an organic regeneration of the body by regular or functional food or in a pharmaceutical presentation as a supplement, 52,53 particularly in the management of chronic diseases and associated co-morbidities. 54 In recent years it has been stressed the regular consumption of soy, berries and cruciferous for its chemopreventive properties.…”

Section: Biological Therapiesmentioning

confidence: 99%

Integrative Medicine: A Health Paradigm of the Future

Cáceres¹

2019

Int J Phytocos Nat Ingred

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Integrative medicine is a medical approach for health and healing which integrates mainstream therapies (conventional), with traditional, complementary and alternative medicines (CAM). It is intended to support those therapies with defined procedures with safety and efficacy so it is considered evidenced-based, but with a holistic and preventive approach. Since late 20th century the interaction of therapists and techniques lead to the recognition of this integrative concept. It is classified into five categories or domains: Alternative medical systems (Ayurveda, Chinese, Kempo), natural products or biological therapies (phytotherapy, trophotherapy, aromatherapy, zootherapy), main-body medicine (yoga, meditation, hypnotherapy), body manipulation practices (chiropractic, massage, shiatzu, lymphatic drainage) and movement-energy therapies (qui gong, reiki, tai chi quan). This approach is expanding among leading universities and is being articulated with conventional medicine for improving public and private health systems worldwide, increasing available therapies from cultural, economic and ecological points of view. It is expected that this concept will lead modern health approach for patients satisfaction, improving health care systems in developing countries and providing fair access to health and beauty by everybody.

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Nutraceuticals: Reviewing their Role in Chronic Disease Prevention and Management

Cited by 33 publications

References 152 publications

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Are Nutraceuticals Beneficial in Chronic Kidney Disease?

Integrative Medicine: A Health Paradigm of the Future

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