Nutriceutical Approach to the Metabolic Syndrome

Comhaire, Frank

doi:10.4172/2161-1017.1000134

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…Anecdotal case studies using this approach have been published, but well-designed clinical trials are lacking so far. Hyperinsulinism and metabolic disturbance due to insulin resistance in PCOS patients can be treated with Metformin, but the Ayurvedic plant extract of Momordica charantia (bitter gourd) may be preferable because of its more favorable toxicological profile (Comhaire, 2014).…”

Section: Discussionmentioning

confidence: 99%

Lowered Plasma Steady-State Levels of Progesterone Combined With Declining Progesterone Levels During the Luteal Phase Predict Peri-Menstrual Syndrome and Its Major Subdomains

et al. 2019

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BackgroundIt is unknown whether lowered steady state levels of sex hormones coupled with changes in those hormones during the menstrual cycle are associated with premenstrual syndrome (PMS).ObjectiveTo examine associations between levels of progesterone and oestradiol during the menstrual cycle and PMS considering different diagnostic criteria for PMS.MethodsForty-one women aged 18–45 years with a regular menstrual cycle completed the Daily Record of Severity of Problems (DRSP) for all 28 consecutive days of the menstrual cycle. Blood was sampled at days 7, 14, 21, and 28 to assay oestradiol and progesterone.ResultsWe developed a new diagnosis of peri-menstrual syndrome, which is characterized by increased DRSP severity in pre and post-menstrual periods and increased scores on the major DRSP dimensions, i.e., depression, physio-somatic symptoms, breast tenderness and appetite, and anxiety. This new diagnosis performed better than classical diagnoses of PMS, including that of the American College of Obstetricians and Gynecologists (ACOG). Lowered steady state levels of progesterone, when averaged over the menstrual cycle, together with declining progesterone levels during the luteal phase predict severity of peri-menstrual symptoms. Steady state levels of oestradiol and declining oestradiol levels during the cycle are also related to DRSP severity although most of these effects appeared to be mediated by progesterone.ConclusionA significant increase in menstrual-cycle related symptoms can best be conceptualized as “peri-menstrual syndrome” and may result from insufficient progesterone production (relative corpus luteum insufficiency), which, in part may result from lowered oestradiol production indicating suboptimal pre-ovulatory follicular development.

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Section: Discussionmentioning

confidence: 99%

Lowered Plasma Steady-State Levels of Progesterone Combined With Declining Progesterone Levels During the Luteal Phase Predict Peri-Menstrual Syndrome and Its Major Subdomains

et al. 2019

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“…Several species, which belong to the Brassicaceae family, represent an important part of the human diet worldwide; indeed, when regularly consumed, they have been found to exert health-promoting effects, such as a reduction in the risk of chronic diseases, particularly cardio-vascular diseases and several types of cancer [ 2 , 3 ]. These effects have been linked to the presence in these plants of phenolics, glucosinolates, carotenoids, tocopherols, and ascorbic acid, well-known antioxidants [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds in Brassicaceae Vegetables with a Role in the Prevention of Chronic Diseases

et al. 2017

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The beneficial role of the Mediterranean diet in the prevention of chronic diseases, including cardiovascular diseases, diabetes, and obesity, is well-recognized. In this context, Brassicaceae are considered important vegetables due to several evidences of their health promoting effects that are associated to bioactive compounds present in the edible parts of the plants. In this review, the mechanisms of action and the factors regulating the levels of the bioactive compounds in Brassicaceae have been discussed. In addition, the impact of industrial and domestic processing on the amount of these compounds have been considered, in order to identify the best conditions that are able to preserve the functional properties of the Brassicaceae products before consumption. Finally, the main strategies used to increase the content of health-promoting metabolites in Brassica plants through biofortification have been analyzed.

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“…In addition, there is risk of acquiring chemoresistance, a great obstacle in clinical management. Therefore, alternative therapies with the use of drugs obtained from medicinal plants including M. charantia are of great importance (Comhaire, 2014;Yung et al, 2016).…”

Section: Anticancer Effectmentioning

confidence: 99%

Phytochemical profile and biological activities of Momordica charantia L. (Cucurbitaceae): A review

Oliveira¹,

Costa²,

Bezerra³

et al. 2018

Afr. J. Biotechnol.

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This study discusses the bioactive composition, supercritical fluid extraction and biological activities of Momordica charantia L. from the last five years. Numerous compounds that have been identified in the extracts of M. charantia, including phytosterols, terpenoids, fatty acids, phenolic compounds, phenolic acids and flavonoids were also discussed. Although, several studies reported the use of organic solvents in the extraction of these compounds, this review emphasized on supercritical fluid extraction (SFE), good selectivity, varied fractions in terms of mass yields and chemical composition obtained, in addition to providing a solvent-free extract. Moreover, the biological effects of M. charantia extracts, including their antidiabetic, neuroprotective, anti-obesogenic, antimalarial, antioxidant, antiinflammatory, antimicrobial and allelopathic activities, were discussed. These biological effects of the extracts of M. charantia can directly affect human health. The findings of this review are important, as they can guide future studies related to obtaining bioactive compounds from M. charantia and its applications.

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Nutriceutical Approach to the Metabolic Syndrome

Cited by 4 publications

References 37 publications

Lowered Plasma Steady-State Levels of Progesterone Combined With Declining Progesterone Levels During the Luteal Phase Predict Peri-Menstrual Syndrome and Its Major Subdomains

Lowered Plasma Steady-State Levels of Progesterone Combined With Declining Progesterone Levels During the Luteal Phase Predict Peri-Menstrual Syndrome and Its Major Subdomains

Bioactive Compounds in Brassicaceae Vegetables with a Role in the Prevention of Chronic Diseases

Phytochemical profile and biological activities of Momordica charantia L. (Cucurbitaceae): A review

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